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The kindling hypothesis of depression posits that each period of depression in someone with major depressive disorder (MDD) causes neurological changes that predispose the person to future episodes. While the first episode of depression is often triggered by major life events, future episodes are less likely to be tied to circumstantial factors ...
Depression is a major cause of morbidity and mortality worldwide, as the epidemiology has shown. [1] Lifetime prevalence estimates vary widely, from 3% in Japan to 17% in India. Epidemiological data shows higher rates of depression in the Middle East, North Africa, South Asia and the United States than in other regions and countries. [2]
Social predictors of depression are aspects of one's social environment that are related to an individual developing major depression.These risk factors include negative social life events, conflict, and low levels of social support, all of which have been found affect the likelihood of someone experiencing major depression, the length of the depression, or the severity of the symptoms.
If left untreated, a typical major depressive episode may last for several months. [32] About 20% of these episodes can last two years or more, while about half end spontaneously. However, even after the major depressive episode is over 20% to 30% of patients have residual symptoms, which can be distressing and associated with disability. [5]
In 1979, Beck, Augustus John Rush, Brian Shaw and Gary Emery published the book "Cognitive therapy of depression", [37] which had the cognitive triad as a major underpinning concept. This mode of therapy became a major part of cognitive behavioral therapy in the 1980s, which became the standard non-pharmaceutical treatment for depression.
The biology of depression is the attempt to identify a biochemical origin of depression, as opposed to theories that emphasize psychological or situational causes. Scientific studies have found that different brain areas show altered activity in humans with major depressive disorder (MDD). [1]
The findings of this study have then been replicated by researchers like Kendler et al. (2005) who showed children experiencing maltreatment and carried the 5HTTLPR gene displayed increased sensitivity to severe depression as adults, [22] Vrshek-Schallhorn et al. (2014) who displayed the interaction between stressful life events and the 5HTTLPR ...
Major depression (also called "major depressive disorder", "clinical depression" or often simply "depression") is a leading cause of disability worldwide, and in 2000 was the fourth leading contributor to the global burden of disease (measured in DALYs); it is also an important risk factor for suicide. [1]
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