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High alkaline phosphatase (ALP) levels may indicate that there’s damage to your liver or that you have a type of bone disorder. Liver damage creates a different type of ALP than bone disorders do.
Alkaline phosphatase may be derived from several sites including the liver, bone, third trimester placenta, intestine, and kidneys. An elevation in alkaline phosphatase with a normal gamma-glutamyl transpeptidase or 5'-nucleotidase suggests a nonhepatic source of alkaline phosphatase.
Elevated alkaline phosphatase occurs when levels of alkaline phosphatase (ALP) exceed the reference range. This group of enzymes has a low substrate specificity and catalyzes the hydrolysis of phosphate esters in a basic environment.
Alkaline phosphatase (ALP) is mainly found in your liver and bones, but small amounts are also in your digestive system, kidneys, and the placenta during pregnancy.
Elevated ALP levels are generally a sign of a liver or bone condition. An obstruction of the liver or damage to it causes ALP levels to rise. Elevated levels can also result from an...
The most common causes of elevated alkaline phosphatase with normal liver enzymes include bone diseases, younger ages, pregnancy, some cancers, partial biliary obstruction, and others. Today, we will deep-dive into all possible causes of the isolated increase in alkaline phosphatase.
Bone alkaline phosphatase is increased at the time of physiological growth spurts, and placental alkaline phosphatase increases towards the end of pregnancy. Outside of these physiological causes of elevated alkaline phosphatase, most disease processes causing alkaline phosphatase rises are due to either hepatobiliary or bone diseases.
Experts believe ALP plays a role in various physiological processes, including detoxification, fat metabolism, and bone formation. This article explores the causes and diagnosis of high ALP and the importance of maintaining balanced levels for overall health. Order from 30+ labs in 20 seconds (DUTCH, Mosaic, Genova & More!)
High alkaline phosphatase (ALP) levels may be a sign of a liver problem or a bone disorder. Liver problems and bone disorders create different types of ALP. But your ALP test results can't tell which type of ALP is high. If your test results show high ALP levels, your provider may order other tests to help figure out what's causing the problem.
Several factors can contribute to high ALP levels, including: Liver conditions such as hepatitis, cirrhosis, or liver tumours can cause elevated ALP levels. Certain conditions, such as Paget's disease, osteomalacia, or bone cancer, can increase ALP production. Conditions such as gallstones or cholecystitis may cause ALP levels to rise.