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Bradykinin (BK) (from Greek brady-'slow' + -kinin, kīn(eîn) 'to move') is a peptide that promotes inflammation.It causes arterioles to dilate (enlarge) via the release of prostacyclin, nitric oxide, and endothelium-derived hyperpolarizing factor and makes veins constrict, via prostaglandin F2, thereby leading to leakage into capillary beds, due to the increased pressure in the capillaries.
The term "relative bradycardia" can refer to a heart rate lower than expected in a particular disease state, often a febrile illness. [8] Chronotropic incompetence (CI) refers to an inadequate rise in heart rate during periods of increased demand, often due to exercise, and is an important sign of SND and an indication for pacemaker implantation.
Negative inotropic agents decrease myocardial contractility and are used to decrease cardiac workload in conditions such as angina. While negative inotropism may precipitate or exacerbate heart failure in the short term, certain beta blockers (e.g. carvedilol , bisoprolol and metoprolol ) have been believed to reduce long-term morbidity and ...
A wealth of recent research, including a new study published this month in the Journal of Alzheimer's Disease, suggests that any type of exercise that raises your heart rate and gets you moving ...
Athletic heart syndrome (AHS) is a non-pathological condition commonly seen in sports medicine in which the human heart is enlarged, and the resting heart rate is lower than normal. The athlete's heart is associated with physiological cardiac remodeling as a consequence of repetitive cardiac loading. [ 3 ]
Chronotropic effects (from chrono-, meaning time, and tropos, "a turn") are those that change the heart rate. Chronotropic drugs may change the heart rate and rhythm by affecting the electrical conduction system of the heart and the nerves that influence it, such as by changing the rhythm produced by the sinoatrial node. Positive chronotropes ...
In a whole, it is the heart's reaction to catecholamines (norepinephrine, epinephrine, dopamine). Conditions that decrease bathmotropy (i.e. hypercarbia) cause the heart to be less responsive to catecholaminergic drugs. A substance that has a bathmotropic effect is known as a bathmotrope.
Exercise mimetics are a proposed class of drugs that aim to do exactly what the name suggests: mimic the health benefits of exercise. SLU-PP-332 and the new compounds fall into this category.