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Steps of the cell cycle. The restriction point occurs between the G 1 and S phases of interphase.. The restriction point (R), also known as the Start or G 1 /S checkpoint, is a cell cycle checkpoint in the G 1 phase of the animal cell cycle at which the cell becomes "committed" to the cell cycle, and after which extracellular signals are no longer required to stimulate proliferation. [1]
The hyper phosphorylation of Rb is considered the late G1 restriction point, after which the cell cannot go backwards in the cell cycle. At this point, E2F 1-3 proteins bind to DNA and transcribe Cyclin A and Cdc 6. [11] Cyclin-dependent kinase inhibitor 1B (CDKN1B), also known as p27, binds to and prevents the activation of CyclinE:Cdk2 by ...
A life history strategy is the "age- and stage-specific patterns" [2] and timing of events that make up an organism's life, such as birth, weaning, maturation, death, etc. [3] These events, notably juvenile development, age of sexual maturity, first reproduction, number of offspring and level of parental investment, senescence and death, depend ...
The cell division cycle protein 20 homolog is an essential regulator of cell division that is encoded by the CDC20 gene [5] [6] in humans. To the best of current knowledge its most important function is to activate the anaphase promoting complex (APC/C), a large 11-13 subunit complex that initiates chromatid separation and entrance into anaphase.
In biology, a biological life cycle (or just life cycle when the biological context is clear) is a series of stages of the life of an organism, that begins as a zygote, often in an egg, and concludes as an adult that reproduces, producing an offspring in the form of a new zygote which then itself goes through the same series of stages, the ...
1 General biology. Toggle General biology subsection ... 1.1 Evolution and origins of life. 1.2 Biochemistry and cell biology. 1.3 Other. ... How did the mitochondria ...
Edward Hitchcock's fold-out paleontological chart in his 1840 Elementary Geology. Although tree-like diagrams have long been used to organise knowledge, and although branching diagrams known as claves ("keys") were omnipresent in eighteenth-century natural history, it appears that the earliest tree diagram of natural order was the 1801 "Arbre botanique" (Botanical Tree) of the French ...