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In prokaryotes, corepressors are small molecules whereas in eukaryotes, corepressors are proteins. A corepressor does not directly bind to DNA, but instead indirectly regulates gene expression by binding to repressors. A corepressor downregulates (or represses) the expression of genes by binding to and activating a repressor transcription factor.
Submission of preprints is accepted by all open access journals. Over the last decade, they have been joined by most subscription journals, however publisher policies are often vague or ill-defined. [1] In general, most publishers that permit preprints require that:
The nuclear receptor co-repressor 2 is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains.In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions.
Transcriptional repression by corepressors is in many ways conceptually comparable to the mediation of receptor transcriptional activation by coactivators, but has an opposite outcome. Recruitment of corepressors, generally occurring in the absence of ligand, depends on a critical conformation of the receptor AF-2 domain, as well as upon ...
Transcription coregulators that activate gene transcription are referred to as coactivators while those that repress are known as corepressors. The mechanism of action of transcription coregulators is to modify chromatin structure and thereby make the associated DNA more or less accessible to transcription.
The submission systems limited to the participating ARPHA journals <100 2020 Pensoft Publishers: Authorea [6] Multidisciplinary: A collaborative writing platform that can be used as preprint server >10,000 2013 Atypon: Beilstein Archives: Multidisciplinary: Preprint server for Beilstein journals >100 2019 Beilstein Institut: BioHackrXiv: Life ...
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Rapid Reports submissions receive expedited peer review, and if accepted are highlighted on the journal's website Archived 2017-11-23 at the Wayback Machine. NeuroForum submissions must meet strict guidelines, and it is recommended that articles that are examined in NeuroForum submissions are pre-approved by the editor-in-chief. [5]
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related to: corepressors in neuroscience journal submission