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Metastatic calcification can occur widely throughout the body but principally affects the interstitial tissues of the vasculature, kidneys, lungs, and gastric mucosa. For the latter three, acid secretions or rapid changes in pH levels contribute to the formation of salts.
May have calcification; Non-progressive; After drugs, such as methysergide or bromocriptine: Diffuse; Possible interstitial pulmonary fibrosis; Cancer-related Primary cancer, mainly mesothelioma: Associated with asbestosis; Progressive thickening; Metastasis or invasion, mainly from lung cancer: Progressive; Nodular changes; Lung tumors
One of the principal causes of arterial stiffening with age is vascular calcification. Vascular calcification is the deposition of mineral in the form of calcium phosphate salts in the smooth muscle-rich medial layer of large arteries including the aorta. DNA damage, especially oxidative DNA damage, causes accelerated vascular calcification. [11]
Potential causes of centrilobular GGOs include pulmonary calcifications from metastatic disease, some types of idiopathic interstitial pneumonias, hypersensitivity pneumonitis, aspiration pneumonitis, cholesterol granulomas, and pulmonary capillary hemangiomastosis. [6]
Rarely, large anterior cervical spine osteophytes may affect the esophagus or the larynx and cause pain, difficulty swallowing [5] [6] or even dyspnea. [7] Similar calcification and ossification may be seen at peripheral entheseal sites, including the shoulder, iliac crest , ischial tuberosity , trochanters of the hip, tibial tuberosities ...
Exposure to certain substances, such as asbestos, can cause generalised fibrosis of the lungs, which may involve the pleura and lead to fibrothorax. [7] Less common causes of fibrothorax include collagen vascular diseases such as systemic lupus erythematosus , sarcoidosis , and rheumatoid arthritis ; kidney failure leading to uraemia ; and side ...
"Pulmonary hyalinizing granuloma" is a lesion characterized by keloid-like fibrosis in the lung and is not granulomatous. Similarly, radiologists often use the term granuloma when they see a calcified nodule on X-ray or CT scan of the chest. They make this assumption since granulomas usually contain calcium, although the cells that form a ...
Ectopic calcification is a pathologic deposition of calcium salts in tissues or bone growth in soft tissues. This can be a symptom of hyperphosphatemia . Formation of osseous tissue in soft tissues such as the lungs, eyes, arteries, or other organs is known as ectopic calcification , dystrophic calcification , or ectopic ossification .