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Aloe emodin (1,8-dihydroxy-3-(hydroxymethyl)anthraquinone) is an anthraquinone and an isomer of emodin present in aloe latex, an exudate from the aloe plant. It has a strong stimulant-laxative action. [1] Aloe emodin is not carcinogenic when applied to the skin, although it may increase the carcinogenicity of some kinds of radiation. [2] [3]
Foslevodopa is a medication which acts as a prodrug for levodopa, originally invented in the 1980s but not developed for medical use at that time. [1] It is approved for use in a subcutaneous infusion as a fixed-dose combination with foscarbidopa for the treatment of Parkinson's disease, under the brand name Vyalev.
Retinyl palmitate, or vitamin A palmitate, is the ester of retinol and palmitic acid, with formula C 36 H 60 O 2.It is the most abundant form of vitamin A storage in animals. [2]
Axons in shiverer mice fail to attain a normal diameter and exhibit altered cytoskeleton structure. [2] Approximately twelve days after birth, shiverer mice begin to exhibit tremors which progressively worsen. They exhibit tonic seizure behavior after weaning and die prematurely, typically between 50 and 100 days after birth. [3]
Humanized mice are commonly used as small animal models in biological and medical research for human therapeutics. [ 2 ] A humanized mouse or a humanized mouse model is one that has been xenotransplanted with human cells and/or engineered to express human gene products, so as to be utilized for gaining relevant insights in the in vivo context ...
The mutation causing SCIDs in mice was discovered by Melvin and Gayle Bosma in 1983 [1] in the CB/17 mouse line. [2] SCIDs occurs in these mice due to a mutation in the gene for protein kinase, DNA activated, catalytic polypeptide (PRKDC), which plays a role in repairing double-stranded DNA breaks.
BALB/c is an albino, laboratory-bred strain of the house mouse from which a number of common substrains are derived. Now over 200 generations from New York in 1920, BALB/c mice are distributed globally, and are among the most widely used inbred strains used in animal experimentation.
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