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2. Discovery and development of proton pump inhibitors - Wikipedia

   en.wikipedia.org/wiki/Discovery_and_development...

   In theory, by using pure esomeprazole the effects on the proton pump will be equal in all patients, eliminating the "poor metabolizer effect" of the racemate omeprazole. It is available as delayed-release capsules or tablets and as esomeprazole sodium for intravenous injection/infusion.

3. Modified-release dosage - Wikipedia

   en.wikipedia.org/wiki/Modified-release_dosage

   Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release [ER, XR, XL] dosage) or to a specific target in the body (targeted-release dosage). [1]

4. Omeprazole - Wikipedia

   en.wikipedia.org/wiki/Omeprazole

   Omeprazole was a subject of a patent litigation in the U.S. [66] The invention involved application of two different coatings to a drug in pill form to ensure that the omeprazole did not disintegrate before reaching its intended site of action in stomach. Although the solution by means of two coating was obvious, the patent was found valid ...

5. Proton-pump inhibitor - Wikipedia

   en.wikipedia.org/wiki/Proton-pump_inhibitor

   The rate of omeprazole absorption is decreased by concomitant food intake. [79] In addition, the absorption of lansoprazole and esomeprazole is decreased and delayed by food. It has been reported, however, that these pharmacokinetic effects have no significant impact on efficacy. [80] [81]

6. Enteric coating - Wikipedia

   en.wikipedia.org/wiki/Enteric_coating

   An enteric coating is a polymer barrier applied to oral medication that prevents its dissolution or disintegration in the gastric environment. [1] This helps by either protecting drugs from the acidity of the stomach, the stomach from the detrimental effects of the drug, or to release the drug after the stomach (usually in the upper tract of the intestine). [2]

7. Omeprazole/amoxicillin/rifabutin - Wikipedia

   en.wikipedia.org/wiki/Omeprazole/amoxicillin/...

   "Omeprazole".Drug Information Portal.U.S. National Library of Medicine. "Amoxicillin".Drug Information Portal.U.S. National Library of Medicine. "Rifabutin".