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  2. Is Sildenafil Safe for This Common Male Problem? - AOL

    www.aol.com/sildenafil-safe-common-male-problem...

    Sildenafil is most commonly prescribed to be taken one time per day in doses between 25 and 100 mg for ED. Your healthcare provider will determine the best dosage for you based on a number of factors.

  3. Your ED Pill Guide: Everything You Need to Know Before ... - AOL

    www.aol.com/ed-pill-guide-everything-know...

    Viagra (or sildenafil) lasts three to five hours after it’s consumed. Cialis (tadalafil) has a half-life of 17.5 hours, meaning this drug lasts up to 36 hours after it’s consumed.

  4. Things You Probably Don't Know About Viagra (Like What It Was ...

    www.aol.com/things-probably-dont-know-viagra...

    Sildenafil’s role as a PDE5 inhibitor might help prevent the thickening of heart muscles, a feature that makes it difficult to pump blood. Viagra has also shown real promise for increasing the ...

  5. PDE5 inhibitor - Wikipedia

    en.wikipedia.org/wiki/PDE5_inhibitor

    Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.

  6. Sildenafil - Wikipedia

    en.wikipedia.org/wiki/Sildenafil

    Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [ 4 ] [ 8 ] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon . [ 9 ]

  7. Erectile dysfunction - Wikipedia

    en.wikipedia.org/wiki/Erectile_dysfunction

    The PDE5 inhibitors sildenafil (Viagra), vardenafil (Levitra) and tadalafil (Cialis) are prescription drugs which are taken by mouth. [10]: 20–21 As of 2018, sildenafil is available in the UK without a prescription. [54]

  8. 5 Must-Know Tips Before Taking Sildenafil 100mg - AOL

    www.aol.com/5-must-know-tips-taking-105700758.html

    For example, in clinical trials of sildenafil, 28 percent of men reported headache (by far the most common side effect) at a dosage of 100mg, compared to just 16 percent of men who used 25mg and ...

  9. PF-00446687 - Wikipedia

    en.wikipedia.org/wiki/PF-00446687

    PF-00446687 is a drug developed by Pfizer for the treatment of erectile dysfunction, which is a non-peptide agonist selective for the melanocortin receptor subtype MC 4.It was found to be active in preliminary human trials, with the 200mg dose being of similar effectiveness to 100mg sildenafil, though lower doses were ineffective.

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