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Evidence-based, trauma-focused psychotherapy is the first-line treatment for PTSD. [1] [2] [3] Psychotherapy is defined as a treatment where a therapist and patient build a therapeutic relationship and focus on the patient's thoughts, attitudes, affect, behavior, and social development to lessen the patient's psychopathologies and functional impairment.
Discontinuation symptoms can be managed by tapering, a gradual reduction in dosage over a period of days, weeks or sometimes months to minimize or prevent withdrawal symptoms. [38] MAOIs, as with most antidepressant medication, may not alter the course of the disorder in a significant, permanent way, so it is possible that discontinuation can ...
Two SSRIs, sertraline (Zoloft) and paroxetine (Paxil), are FDA-approved to treat PTSD. Other SSRIs are sometimes prescribed off-label to treat PTSD, meaning they’re used for something they’re ...
More severe symptoms include fever, seizures, irregular heartbeat, delirium, and coma. [76] [77] [11] If signs or symptoms arise, discontinue treatment with serotonergic agents immediately. [76] It is recommended to washout 4 to 5 half-lives of the serotonergic agent before using an MAO inhibitor. [78]
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For example, cocaine, which non-selectively inhibits the reuptake of serotonin, norepinephrine, and dopamine, is an SRI but not an SSRI. SRIs are used predominantly as antidepressants (e.g., SSRIs, SNRIs, and TCAs), though they are also commonly used in the treatment of other psychological conditions such as anxiety disorders and eating disorders.
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions. SSRIs increase the extracellular level of the neurotransmitter serotonin by limiting its reabsorption (reuptake) into the ...
The following antidepressants are available both with a prescription and over-the-counter: Ademetionine [ S -Adenosyl- L -methionine (SAMe)] (Heptral, Transmetil, Samyl) – cofactor in monoamine neurotransmitter biosynthesis
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