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SSRIs are a type of antidepressant often used for PTSD. These medications work by optimizing serotonin — colloquially referred to as the “feel-good chemical” — activity in the brain.
As with other antidepressants, MAOIs carry a “black box” warning from the FDA about an increased risk of suicidal thoughts or behaviors in children, teenagers and young adults. Withdrawal ...
Discontinuation symptoms can be managed by tapering, a gradual reduction in dosage over a period of days, weeks or sometimes months to minimize or prevent withdrawal symptoms. [38] MAOIs, as with most antidepressant medication, may not alter the course of the disorder in a significant, permanent way, so it is possible that discontinuation can ...
Evidence-based, trauma-focused psychotherapy is the first-line treatment for PTSD. [1] [2] [3] Psychotherapy is defined as a treatment where a therapist and patient build a therapeutic relationship and focus on the patient's thoughts, attitudes, affect, behavior, and social development to lessen the patient's psychopathologies and functional impairment.
Another type of antidepressant is a monoamine oxidase inhibitor (MAOI), which is thought to block the action of monoamine oxidase, an enzyme that breaks down serotonin and norepinephrine. MAOIs are not used as first-line treatment due to the risk of hypertensive crisis related to the consumption of foods containing the amino acid tyramine. [22]
In addition, the nonselective MAOIs and the TCA SNRIs are widely believed to have an efficacy that is superior to the SSRIs normally picked as the first-line choice of agents for/in the treatment of MDD and related disorders. [31] The reason for this is based on the fact that SSRIs are safer than nonselective MAOIs and TCAs.
This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification. Chemical/generic names are listed first, with brand names in parentheses.
The pharmacology of antidepressants is not entirely clear.. The earliest and probably most widely accepted scientific theory of antidepressant action is the monoamine hypothesis (which can be traced back to the 1950s), which states that depression is due to an imbalance (most often a deficiency) of the monoamine neurotransmitters (namely serotonin, norepinephrine and dopamine). [1]