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The mononuclear spot test or monospot test, a form of the heterophile antibody test, [1] is a rapid test for infectious mononucleosis due to Epstein–Barr virus (EBV). It is an improvement on the Paul–Bunnell test. [2] The test is specific for heterophile antibodies produced by the human immune system in response to EBV infection.
Heterophile antibodies can arise in non-EBV infections. False positive monospot tests may occur in cases of HIV, lymphoma, or systemic lupus erythematosus. Other assays for detection of EBV are available, including serologic markers. [7] An important clinical pearl for heterophile antibodies is they can also be seen in genetic immunodeficiencies.
Blood test results for persons with infectious mononucleosis include an elevated white blood cell count, an increased percentage of atypical mononuclear cells. Liver enzymes are often elevated. A positive "mono spot" test is useful in confirming the diagnosis but a negative result does not rule out primary EBV infection.
The CDC says positive results are usually pretty accurate—but the tests are less likely to detect the virus when you don’t have symptoms. ... or confirm the results with a PCR test. PCR tests ...
The Food and Drug Administration (FDA) has approved at least 25 companies to sell at-home tests, ranging from $109-$155 each, with varying amounts of coverage from insurance, based on state and ...
False positive results on home COVID antigen tests are rare, especially when it is someone who is symptomatic, says Amesh Adalja, M.D., a senior scholar at the Johns Hopkins Center for Health ...
The false positive rate (FPR) is the proportion of all negatives that still yield positive test outcomes, i.e., the conditional probability of a positive test result given an event that was not present. The false positive rate is equal to the significance level. The specificity of the test is equal to 1 minus the false positive rate.
On/Go One Rapid COVID-19 Self-Test Kit with Test-to-Treat App, 12 Pack, 12 Tests Total, 15-Minute Results, FDA EUA Authorized, Easy to Use at Home, Fast and Accurate On/Go COVID-19 Antigen Self ...