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The genome of Pseudomonas aeruginosa consists of a relatively large circular chromosome (5.5–6.8 Mb) that carries between 5,500 and 6,000 open reading frames, and sometimes plasmids of various sizes depending on the strain. [11] Comparison of 389 genomes from different P. aeruginosa strains showed that just 17.5% is shared.
Pseudomonas infection refers to a disease caused by one of the species of the genus Pseudomonas. P. aeruginosa is a germ found in the environment and it is an opportunistic human pathogen most commonly infecting immunocompromised patients, such as those with cancer, diabetes, cystic fibrosis, [1] severe burns, AIDS, [2] or people who are very ...
Hot tub folliculitis, also called Pseudomonal folliculitis or Pseudomonas aeruginosa folliculitis, is a common type of folliculitis featuring inflammation of hair follicles and surrounding skin. [1]: 272 This condition is caused by an infection of the skin and hair follicles by the bacterium Pseudomonas aeruginosa.
Ceftazidime, sold under the brand name Fortaz among others, is a third-generation cephalosporin antibiotic useful for the treatment of a number of bacterial infections. [1] [5] Specifically it is used for joint infections, meningitis, pneumonia, sepsis, urinary tract infections, malignant otitis externa, Pseudomonas aeruginosa infection, and vibrio infection. [1]
Pseudomonas aeruginosa is highly contagious and has displayed resistance to antibiotic treatments, making it difficult to manage effectively. Some strains of Pseudomonas are known to target white blood cells in various mammal species , posing risks to humans, cattle, sheep, and dogs alike.
The Pseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa. [1] Vibrio cholerae produces a similar protein called the Cholix toxin 2] It inhibits elongation factor-2. It does so by ADP-ribosylation of EF2 using NAD+. This then causes the elongation of polypeptides to cease.
Panobacumab (proposed INN) is a monoclonal antibody designed as an antibacterial against Pseudomonas aeruginosa. [1] It is a fully human pentameric IgM antibody with a mouse J chain. [1] Panobacumab molecule consisting of five base units. 1: Base unit. 2: Heavy chains. 3: Light chains. 4: J chain. 5: Intermolecular disulfide bonds.
Pseudomonas aeruginosa. The molecule 2-heptyl-3-hydroxy-4-quinolone, also named the Pseudomonas quinolone signal (PQS), has been discovered as an intracellular link between the two major quorum sensing systems of P. aeruginosa; the las and rhl systems. [1]
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