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[69] [76] As both the IGF-1R and the EGFR are independently essential for mammary gland development, and as combined application of IGF-1 and EGF, through their respective receptors, has been found to synergistically stimulate the growth of human breast epithelial cells, these growth factor systems appear to work together in mediating breast ...
A mammary gland is an exocrine gland in humans and other mammals that produces milk to feed young offspring.Mammals get their name from the Latin word mamma, "breast".The mammary glands are arranged in organs such as the breasts in primates (for example, humans and chimpanzees), the udder in ruminants (for example, cows, goats, sheep, and deer), and the dugs of other animals (for example, dogs ...
The mammary ridge is primordial for the mammary glands on the chest in humans, and is associated with mammary gland and breast development. In human embryogenesis, the mammary ridge usually appears as a narrow, microscopic ectodermal thickening during the first seven weeks of pregnancy and grows caudally as a narrow, linear ridge. [1]
During this time, the mammary glands grow in size and volume and begin resting on the chest. These development stages of secondary sex characteristics (breasts, pubic hair, etc.) are illustrated in the five-stage Tanner scale. [48] During thelarche, the developing breasts are sometimes of unequal size, and usually the left breast is slightly ...
However, the relative affinities of hPL and prolactin for the human prolactin receptor have yet to be published and the effects of hPL on normal human mammary epithelial tissue have not yet been investigated, and so a definitive role of hPL in human mammary gland development during pregnancy has not been established at present. [6]
Lactiferous ducts are ducts that converge and form a branched system connecting the nipple to the lobules of the mammary gland.When lactogenesis occurs, under the influence of hormones, the milk is moved to the nipple by the action of smooth muscle contractions along the ductal system to the tip of the nipple.
Terminal end buds (TEBs) are highly proliferative structures at the ends of elongating lactiferous ducts which are involved in development of the mammary glands. [1] TEBs are responsible for the formation of the mammary ductal tree during female puberty. [1]
The number for prolactin cells in a pregnant female will increase to allow for breast tissue development. Prolactin is involved in the maturation of mammary glands and their secretion of milk in association with oxytocin, estrogen, progesterone, glucocorticoids, and others. Prolactin has numerous other effects in both sexes.