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Sleep is known to play an important role in the etiology and maintenance of bipolar disorder. [1] Patients with bipolar disorder often have a less stable and more variable circadian activity. [2] Circadian activity disruption can be apparent even if the person concerned is not currently ill. [3] [4]
In an open trial aimed at prevention, adolescents (N=13) who were identified as high risk for bipolar disorder, due to having a first-degree relative with BD, received IPSRT. [22] Significant changes in sleep/circadian patterns (i.e. less weekend sleeping in and oversleeping) were observed.
Research shows that combining talk therapy with medication can help bipolar patients stick to ... Lack of sleep can potentially trigger mania for those with bipolar disorder. To improve sleep ...
The most common sleep-related symptom of bipolar disorder is insomnia, in addition to hypersomnia, nightmares, poor sleep quality, OSA, extreme daytime sleepiness, etc. [27] Moreover, animal models have shown that sleep debt can induce episodes of bipolar mania in laboratory mice, but these models are still limited in their potential to explain ...
The response rate to sleep deprivation is generally agreed to be approximately 40-60%. A 2017 meta-analysis of 66 sleep studies with partial or total sleep deprivation in the treatment of depression found that the overall response rate (immediate relief of symptoms) to total sleep deprivation was 50.4% of individuals, and the response rate to partial sleep deprivation was 53.1% [3] In 2009, a ...
The poor response from some bipolar patients to treatment has given evidence to the concept of treatment-resistant bipolar disorder. [ 158 ] [ 159 ] Guidelines to the definition of treatment-resistant bipolar disorder and evidence-based options for its management were reviewed in 2020.
In light of associations between bipolar and circadian abnormalities (such as decreased need for sleep and increased sleep latency), polymorphisms in the CLOCK gene have been tested for association, although findings have been inconsistent, [6] and one meta analysis has reported no association with either bipolar or major depressive disorder. [14]
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related to: sleep in bipolar patients