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Protein-bound paclitaxel, also known as nanoparticle albumin–bound paclitaxel or nab-paclitaxel, is an injectable formulation of paclitaxel used to treat breast cancer, lung cancer and pancreatic cancer, among others. Paclitaxel kills cancer cells by preventing the normal breakdown of microtubules during cell division.
Paclitaxel, sold under the brand name Taxol among others, is a chemotherapy medication used to treat ovarian cancer, esophageal cancer, breast cancer, lung cancer, Kaposi's sarcoma, cervical cancer, and pancreatic cancer. [11] It is administered by intravenous injection. [11] There is also an albumin-bound formulation. [11]
ABRAXANE is an albumin-bound form of paclitaxel that is manufactured using patented nab ® technology. ABRAXANE is formulated with albumin, a human protein, and is free of solvents.
Nanoparticle albumin-bound (nab) paclitaxel is an Albumin bound with high affinity to the hydrophobic molecules of paclitaxel, which results in higher accumulation of the cytotoxic drug in tumors. A recent meta-analysis showed that when compared to Paclitaxel, nab-paclitaxel has significant beneficial effects in terms of overall response rate ...
The bound portion may act as a reservoir or depot from which the drug is slowly released as the unbound form. Since the unbound form is being metabolized and/or excreted from the body, the bound fraction will be released in order to maintain equilibrium. Since albumin is alkalotic, acidic and neutral drugs will primarily bind to albumin.
In Terminal 4 at Los Angeles International Airport, a TSA officer flagged a carry-on bag with 82 consumer-grade fireworks, three knives, two replica firearms and a canister of pepper spray.
Paclitaxel total synthesis in organic chemistry is a major ongoing research effort in the total synthesis of paclitaxel (Taxol). [1] This diterpenoid is an important drug in the treatment of cancer but, also expensive because the compound is harvested from a scarce resource, namely the Pacific yew ( Taxus brevifolia ).
Finding the motivation to work out can be tough, but adding cats to the mix is bound to make it more exciting. Echo Wang, CEO and founder of Yoga Kawa, says: "Yoga with cats is such a delightful ...