Search results
Results from the WOW.Com Content Network
ISGs are genes whose expression can be stimulated by interferon, but may also be stimulated by other pathways. [1] Interferons are a type of protein called a cytokine, which is produced in response to infection. [9] When released, they signal to infected cells and other nearby cells that a pathogen is present. [9]
Interferome is an online bioinformatics database of interferon-regulated genes (IRGs). [1] These Interferon Regulated Genes are also known as Interferon Stimulated Genes (ISGs). The database contains information on type I (IFN alpha, beta), type II (IFN gamma) and type III (IFN lambda) regulated genes and is regularly updated.
ISG15 was originally identified in the late 1970s as a 15-kDa protein produced in response to type I interferon, a potent class of antiviral cytokines. [19] Given the molecular weight, it was originally termed "a 15-kDa protein", but later renamed interferon-stimulated-gene-15 when the cassette of interferon-stimulated genes were recognized.
STAT1 homodimers are involved in type II interferon signalling, and bind to the GAS (Interferon-Gamma Activated Sequence) promoter to induce expression of interferon stimulated genes (ISG). In type I interferon signaling, STAT1-STAT2 heterodimer combines with IRF9 (Interferon Response Factor) to form ISGF3 (Interferon Stimulated Gene Factor ...
Stimulator of interferon genes (STING), also known as transmembrane protein 173 (TMEM173) and MPYS/MITA/ERIS is a protein that in humans is encoded by the STING1 gene. [ 5 ] STING plays an important role in innate immunity .
It took another fifteen to twenty years, using somatic cell genetics, to show that the interferon action gene and interferon gene reside in different human chromosomes. [71] [72] [73] The purification of human beta interferon did not occur until 1977. Y.H. Tan and his co-workers purified and produced biologically active, radio-labeled human ...
Interferon-induced protein with tetratricopeptide repeats 3, also known as interferon-stimulated gene 49 ... is a protein that in humans is encoded by the IFIT3 gene. ...
Interferon-induced protein with tetratricopeptide repeats 2 (commonly termed IFIT2) is a protein that in humans is directed to be produced by the IFIT2 gene. [5] [6] [7] Previously, this gene was termed the G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, or P54 gene and the protein that it directs to be produced was termed the G10P2, GARG-39, IFI-54, IFI-54K, IFI54 ...