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2. Multiple drug resistance - Wikipedia

   en.wikipedia.org/wiki/Multiple_drug_resistance

   Multiple drug resistance (MDR), multidrug resistance or multiresistance is antimicrobial resistance shown by a species of microorganism to at least one antimicrobial drug in three or more antimicrobial categories. [1] Antimicrobial categories are classifications of antimicrobial agents based on their mode of action and specific to target ...

3. Multidrug-resistant Gram-negative bacteria - Wikipedia

   en.wikipedia.org/wiki/Multidrug-resistant_gram...

   MDR strains of Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii have become of most concern because they have been reported by hospitals all around the United States. There are many factors which could be contributed to the existence and spread of MDR gram-negative bacteria such as the: overuse or misuse of existing ...

4. Multidrug-resistant bacteria - Wikipedia

   en.wikipedia.org/wiki/Multidrug-resistant_bacteria

   Multidrug-resistant bacteria (MDR bacteria) are bacteria that are resistant to three or more classes of antimicrobial drugs. [1] MDR bacteria have seen an increase in prevalence in recent years [ clarification needed ] [ 2 ] and pose serious risks to public health .

5. P-glycoprotein - Wikipedia

   en.wikipedia.org/wiki/P-glycoprotein

   P-gp is a 170 kDa transmembrane glycoprotein, which includes 10–15 kDa of N-terminal glycosylation.The N-terminal half of the protein contains six transmembrane helixes, followed by a large cytoplasmic domain with an ATP-binding site, and then a second section with six transmembrane helixes and an ATP-binding domain that shows over 65% of amino acid similarity with the first half of the ...

6. Multidrug resistance pump - Wikipedia

   en.wikipedia.org/wiki/Multidrug_resistance_pump

   MDR pumps in the cell membrane extrudes many foreign substances out of the cells and some pumps can have a broad specificity. [1] MDR pumps exist in animals, fungi, and bacteria and likely evolved as a defense mechanism against harmful substances. There are seven families of MDRs and are grouped by homology, energy source, and overall structure ...

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