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  2. Coma cocktail - Wikipedia

    en.wikipedia.org/wiki/Coma_cocktail

    The intention is to work against various causes of a coma seen in an emergency setting including drug overdoses and hypoglycemia. The coma cocktail is sometimes colloquially referred to as a “party pack” by paramedics in the pre-hospital emergency medical services field. [2] Coma-cocktail

  3. Drug accumulation ratio - Wikipedia

    en.wikipedia.org/wiki/Drug_accumulation_ratio

    The accumulation ratio of a specific drug in humans is determined by clinical studies. According to a 2013 analysis, such studies are typically done with 10 to 20 subjects who are given one single dose followed by a washout phase of seven days , and then seven to 14 repeated doses to reach steady state conditions. Blood samples are drawn 11 ...

  4. Area under the curve (pharmacokinetics) - Wikipedia

    en.wikipedia.org/wiki/Area_under_the_curve...

    Another use is in the therapeutic drug monitoring of drugs with a narrow therapeutic index. For example, gentamicin is an antibiotic that can be nephrotoxic (kidney damaging) and ototoxic (hearing damaging); measurement of gentamicin through concentrations in a patient's plasma and calculation of the AUC is used to guide the dosage of this drug ...

  5. Clearance (pharmacology) - Wikipedia

    en.wikipedia.org/wiki/Clearance_(pharmacology)

    In pharmacology, clearance is a pharmacokinetic parameter representing the efficiency of drug elimination. This is the rate of elimination of a substance divided by its concentration. [ 1 ] The parameter also indicates the theoretical volume of plasma from which a substance would be completely removed per unit time.

  6. Therapeutic index - Wikipedia

    en.wikipedia.org/wiki/Therapeutic_index

    Recognizing drug candidates with potentially suboptimal TI at the earliest possible stage helps to initiate mitigation or potentially re-deploy resources. TI is the quantitative relationship between pharmacological efficacy and toxicological safety of a drug, without considering the nature of pharmacological or toxicological endpoints themselves.

  7. Paramedic questions drug many say is 'safe' after his patient ...

    www.aol.com/news/paramedic-questions-drug-many...

    In 2021, Colorado enacted a new law and new health policies restricting the purposes for which the drug could be used by paramedics, following McClain’s tragedy. Currently, Colorado does not ...

  8. Equianalgesic - Wikipedia

    en.wikipedia.org/wiki/Equianalgesic

    Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1] Tables of this general type are also available for NSAIDs , benzodiazepines , depressants , stimulants , anticholinergics and others.

  9. Broselow tape - Wikipedia

    en.wikipedia.org/wiki/Broselow_tape

    Specifically, for drug dosing, the patient's length-based dosing zone can be adjusted up one color zone if the child appears overweight. Thus, incorporating a visual estimate of whether the child is overweight provides a simple method to predict actual patient weight that appears to be clinically relevant given the rise in obesity in the U.S ...