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Plague (Yersinia pestis): Has historically been used as the first-line treatment. However streptomycin is approved for this purpose only by the US Food and Drug Administration. [medical citation needed] In veterinary medicine, streptomycin is the first-line antibiotic for use against gram negative bacteria in large animals (horses, cattle ...
1944 – streptomycin, the first aminoglycoside [2] 1947 – sulfadiazine; 1948 – chlortetracycline, the first tetracycline; 1949 – chloramphenicol, the first amphenicol [2] 1949 – neomycin; 1950 – oxytetracycline; 1950 – penicillin G procaine; 1952 – erythromycin, the first macrolide [2] 1954 – benzathine penicillin; 1955 ...
Streptomycin was the first effective drug against gram-negative bacteria [3] and the first antibiotic used to cure tuberculosis. Waksman is credited with coining the term antibiotics to describe antibacterials derived from other living organisms, for example penicillin , though the term was used by the French dermatologist François Henri ...
Streptomycin is noteworthy because it is the first significant antibiotic discovered after penicillin, the first systemic antibiotic discovered in America, the first antibiotic active against tuberculosis, and the first-line treatment for plague.
The first individual treated was a 21-year-old girl who had advanced pulmonary tuberculosis and was given streptomycin on 20 November 1944. [27] By 1946, experiments conducted under the projects of Merck in the UK and USA had proven streptomycin's effectiveness against TB, bubonic plague , cholera, typhoid fever, and other penicillin-resistant ...
Streptomycin was the first effective antibiotic against M. tuberculosis. [113] This discovery is generally considered the beginning of the modern era of tuberculosis. [ 113 ] Para-aminosalicylic acid , discovered in 1946, was used in combination with Streptomycin to reduce the emergence of drug resistant variants, which greatly improved patient ...
Streptomycin is the first-in-class aminoglycoside antibiotic. It is derived from Streptomyces griseus and is the earliest modern agent used against tuberculosis. Streptomycin lacks the common 2-deoxystreptamine moiety (image right, below) present in most other members of this class.
Horton Corwin Hinshaw Sr. (August 1, 1902, Iowa Falls, Iowa – December 28, 2000, San Rafael, California) was an American pulmonologist, known for the use of streptomycin as the first effective antibiotic for the treatment of tuberculosis (TB). [1] [2]