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The system of DNA profiling used today is based on PCR and uses simple sequences [6] or short tandem repeats (STR). This method uses highly polymorphic regions that have short repeated sequences of DNA (the most common is 4 bases repeated, but there are other lengths in use, including 3 and 5 bases).
VisualVM is a visual tool integrating several commandline JDK tools and lightweight profiling capabilities. It is bundled with the Java Development Kit since version 6, update 7. FusionReactor, Java application performance monitoring - low overhead, production grade tools for production debugging, code profiling, memory and thread analysis
.NET: Can attach a profiling agent as a COM server to the CLR using Profiling API. Like Java, the runtime then provides various callbacks into the agent, for trapping events like method JIT / enter / leave, object creation, etc. Particularly powerful in that the profiling agent can rewrite the target application's bytecode in arbitrary ways.
Short Tandem Repeat (STR) analysis is the modern day equivalent of RFLP. Not only does STR analysis use less of a sample to analyze DNA, but it also is a part of a larger process called Polymerase Chain Reaction (PCR). PCR is a process that can be used to quickly reproduce up to a billion copies of a singular segment of DNA. [3]
Moreover, some of them make possible to analyse and model RNA-Seq protocols. BEERS Simulator is formatted to mouse or human data, and paired-end reads sequenced on Illumina platform. Beers generates reads starting from a pool of gene models coming from different published annotation origins.
A microsatellite is a tract of tandemly repeated (i.e. adjacent) DNA motifs that range in length from one to six or up to ten nucleotides (the exact definition and delineation to the longer minisatellites varies from author to author), [1] [6] and are typically repeated 5–50 times.
STR polymorphisms are genetic markers that may be used to identify a DNA sequence. The FBI analyses 13 specific STR loci for their database. These may be used in many areas of genetics in addition to their forensic uses. One can think of a STR multiplex system as a collection of specific STRs which are positionally conserved on a target genome.
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