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Scheme of the complement system. The complement system, also known as complement cascade, is a part of the humoral, innate immune system and enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. [1]
Illustration of a eukaryotic cell membrane Comparison of a eukaryotic vs. a prokaryotic cell membrane. The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates and protects the interior of a cell from the outside environment (the extracellular space).
Membrane attack complex (Terminal complement complex C5b-9) A membrane attack complex attached to a pathogenic cell The membrane attack complex (MAC) or terminal complement complex (TCC) is a complex of proteins typically formed on the surface of pathogen cell membranes as a result of the activation of the host's complement system, and as such is an effector of the immune system.
The components of bilayers are distributed unequally between the two surfaces to create asymmetry between the outer and inner surfaces. [2] This asymmetric organization is important for cell functions such as cell signaling. [3] The asymmetry of the biological membrane reflects the different functions of the two leaflets of the membrane. [4]
A hybrid cell line is a fusion of cells from two different cell types. When the membrane of two cells merge, the nuclei combine to form a polykaryote (poly- multiple; karyon- chromosome). [1] These fusions can happen spontaneously as in the case of tumor hybrid cells, or may be induced by a variety of laboratory techniques.
In hemifusion, the lipid constituents of the outer leaflet of the two bilayers can mix, but the inner leaflets remain distinct. The aqueous contents enclosed by each bilayer also remain separated. Fusion is involved in many cellular processes, particularly in eukaryotes since the eukaryotic cell is extensively sub-divided by lipid bilayer ...
The most important application of membrane fusion is in the production of hybridomas which are cells that arise as a result of the fusion of antibody-secreting and immortal B-cells. Hybridomas are used in the industry for the production of monoclonal antibodies. Membrane fusion also has a major role in cancer immunotherapy.
Two's complement is the most common method of representing signed (positive, negative, and zero) integers on computers, [1] and more generally, fixed point binary values. Two's complement uses the binary digit with the greatest value as the sign to indicate whether the binary number is positive or negative; when the most significant bit is 1 the number is signed as negative and when the most ...