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Cyproheptadine, sold under the brand name Periactin among others, is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. It was patented in 1959 and came into medical use in 1961. [ 5 ]
Cyproheptadine, a non-selective serotonin receptor antagonist (including of the serotonin 5-HT 2A receptor), is used as an antidote in the treatment of serotonin syndrome (or serotonin toxicity) caused by serotonergic drugs, including the toxicity of serotonergic psychedelics like the NBOMe drugs.
Cyproheptadine; Common structural features. Two aromatic rings, connected to a central carbon, nitrogen or CO; Spacer between the central X and the amine, usually 2 ...
All three of these agents, pizotifen, cyproheptadine, and clozapine act as non-selective monoamine receptor antagonists. [10] Pizotifen also fully blocks the effects of serotonergic psychedelics , including LSD , mescaline , 5-MeO-DMT , and DOM , in drug discrimination tests.
AH-1058 is a lipophilic antiarrhythmic calcium channel blocker synthesized by the Pharmaceutical Research Laboratories of Ajinomoto Co., Inc in Kawasaki, Japan. [1] It is derived from cyproheptadine, a compound with known antiserotonic, antihistaminic and calcium channel blocking properties.
Apetamin is a potentially dangerous figure-augmentation product. [1] [2] It is a syrup containing cyproheptadine, the amino acid lysine, and some vitamins.Cyproheptadine, the active ingredient, is an antihistamine and a hepatotoxin that has many effects on the body, including increased appetite, fatigue, and drowsiness. [3]
Promethazine and other first generation antihistamines with a tricyclic structure were discovered in the 1940s.; Chlorpromazine, derived from promethazine originally as a sedative, was found to have neuroleptic properties in the early 1950s, and was the first typical antipsychotic.
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