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  2. Cold agglutinin disease - Wikipedia

    en.wikipedia.org/wiki/Cold_agglutinin_disease

    Cold agglutinin disease (CAD) is a rare autoimmune disease characterized by the presence of high concentrations of circulating cold sensitive antibodies, usually IgM and autoantibodies that are also active at temperatures below 30 °C (86 °F), [1] directed against red blood cells, causing them to agglutinate and undergo lysis. [2]

  3. Cold autoimmune hemolytic anemia - Wikipedia

    en.wikipedia.org/wiki/Cold_autoimmune_hemolytic...

    Cold agglutinins develop in more than 60% of patients with infectious mononucleosis, but hemolytic anemia is rare. Classic chronic cold agglutinin disease is idiopathic, associated with symptoms and signs in relation to cold exposure.

  4. Cold sensitive antibodies - Wikipedia

    en.wikipedia.org/wiki/Cold_sensitive_antibodies

    Cold agglutinins can cause two pathological conditions, that are, primary cold agglutinin disease (CAD) [3] and secondary cold agglutinin syndrome (CAS), [2] both of which are sole two subtypes of cold agglutinin disease. Primary cold agglutinin disease is idiopathic, meaning the phenomenons of agglutinations of the red blood cells and ...

  5. Autoimmune hemolytic anemia - Wikipedia

    en.wikipedia.org/wiki/Autoimmune_hemolytic_anemia

    Cold-type AIHA usually reacts with antisera to complement and occasionally to the above antibodies. This is the case in both cold agglutinin disease and cold paroxysmal hematuria. In general, mixed warm and cold AIHA shows a positive reaction to IgG and complement, sometimes IgG alone, and sometimes complement alone.

  6. Paroxysmal cold hemoglobinuria - Wikipedia

    en.wikipedia.org/wiki/Paroxysmal_cold_hemoglobinuria

    Testing with polyspecific and IgG-specific antiglobulin agents is usually negative, and that with C3-specific agent may be positive. On excluding warm autoimmune hemolytic anemia (WAIHA), the cold agglutinin titer should be examined for cold agglutinin disease (CAD). The diagnosis of PCH is suspected when both WAIHA and CAD are excluded.

  7. Cold hands are common in winter. When are they a sign of a ...

    www.aol.com/lifestyle/cold-hands-common-winter...

    Along with feeling cold, if you notice “your hands have significant color change, numbness, weakness or pain, it could be from an underlying vascular disease, neurologic problems or Raynaud’s ...

  8. Red cell agglutination - Wikipedia

    en.wikipedia.org/wiki/Red_cell_agglutination

    Red cell agglutination in a patient with cold agglutinin disease. In hematology, red cell agglutination or autoagglutination is a phenomenon in which red blood cells clump together, forming aggregates. It is caused by the surface of the red cells being coated with antibodies.

  9. A man and his mailbox: How a dispute over rural mail delivery ...

    www.aol.com/news/man-mailbox-dispute-over-rural...

    On a cold December afternoon, standing next to the empty wood frame where his mailbox used to be, Chuck Klein tried to explain why he’s spent so much time the past few years sending emails to ...

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