Search results
Results from the WOW.Com Content Network
A 2020 Cochrane systematic review did not find enough evidence of reduction of all-cause mortality, serious adverse events, cardiovascular mortality, non-fatal myocardial infarction, non-fatal stroke or end-stage renal disease when comparing metformin monotherapy to meglitinide for the treatment of type 2 diabetes.
A Cochrane systematic review from 2011 showed that treatment with Sulfonylureas did not improve control of glucose levels more than insulin at 3 nor 12 months of treatment. [28] This same review actually found evidence that treatment with Sulfonylureas could lead to earlier insulin dependence, with 30% of cases requiring insulin at 2 years. [28]
A 2020 Cochrane systematic review did not find enough evidence of reduction of all-cause mortality, serious adverse events, cardiovascular mortality, non-fatal myocardial infarction, non-fatal stroke or end-stage renal disease when comparing metformin monotherapy to dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes. [25]
Aldose reductase activity increases as the glucose concentration rises in diabetes in those tissues that are not insulin sensitive, which include the lenses, peripheral nerves, and glomerulus. Sorbitol does not diffuse through cell membranes easily and therefore accumulates, causing osmotic damage which leads to retinopathy and neuropathy.
A systematic review and network meta-analysis comparing SGLT-2 inhibitors, GLP-1 agonists, and DPP-4 inhibitors demonstrated that use of SGLT2 inhibitors was associated with a 20% reduction in death compared with placebo or no treatment. [7] Another systematic review discussed the mechanisms by which SGLT-2 inhibitors improve cardio-renal ...
Journal of Diabetes Investigation. 2014 " Intake of sugar-sweetened beverages and weight gain: a systematic review. " The American Journal of Clinical Nutrition.
Get AOL Mail for FREE! Manage your email like never before with travel, photo & document views. Personalize your inbox with themes & tabs. You've Got Mail!
Diabetes: Diabetes: American Diabetes Association: English: 1952–present Diabetes and Vascular Disease Research: Diabetes: SAGE Publishing: English: 2004–present Diabetes Care: Diabetes: American Diabetes Association: English: 1978–present Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy: Diabetes: Dove Medical Press: English ...