Ads
related to: treponema pallidum antibodies testcreative-biolabs.com has been visited by 10K+ users in the past month
Search results
Results from the WOW.Com Content Network
The fluorescent treponemal antibody absorption (FTA-ABS) test is a diagnostic test for syphilis.Using antibodies specific for the Treponema pallidum species, such tests would be assumed to be more specific than non-treponemal testing such as VDRL but have been shown repeatedly to be sensitive but not specific for the diagnosis of neurosyphilis in cerebrospinal fluid (CSF).
TPHA is an indirect hemagglutination assay used for the detection and titration of antibodies against the causative agent of syphilis, Treponema pallidum subspecies pallidum. [citation needed] In the test, red blood cells (erythrocytes) are sensitized with antigens from T. pallidum pallidum. The cells then aggregate on the surface of a test ...
It is one of several nontreponemal tests for syphilis (along with the Wassermann test and the VDRL test). The term reagin means that this test does not look for antibodies against the bacterium itself, Treponema pallidum, but rather for antibodies against substances released by cells when they are damaged by T. pallidum (cardiolipin and lecithin).
The CSF is tested for antibodies for specific Treponema pallidum antigens. The preferred test is the VDRL test, which is sometimes supplemented by fluorescent treponemal antibody absorption test (FTA-ABS). [1] [2] [3] Historically, the disease was studied under the Tuskegee study, often cited as an example of unethical human experimentation.
There are a number of treponemal-specific tests such as the fluorescent treponemal antibody-absorption test, T. pallidum hemagglutination assays , and the microhemagglutination assay . [citation needed] The MHA-TP is used to confirm a syphilis infection after another method tests positive for the syphilis bacteria.
Treponema pallidum subspecies pallidum is a spiral-shaped, Gram-negative, highly mobile bacterium. [11] [22] Two other human diseases are caused by related Treponema pallidum subspecies, yaws (subspecies pertenue) and bejel (subspecies endemicum), and one further caused by the very closely related Treponema carateum, pinta.
Treponema pallidum pallidum is a motile spirochete that is generally acquired by close sexual contact, entering the host via breaches in squamous or columnar epithelium. The organism can also be transmitted to a fetus by transplacental passage during the later stages of pregnancy, giving rise to congenital syphilis. [ 53 ]
Additionally these tests may show false-negative when the patient's antibody titer is very high due to a hook effect (also called a prozone effect). Because of the issues with false positives, confirmation with a second treponemal test that is specific for T. pallidum antibodies is recommended. [5] [6]
Ads
related to: treponema pallidum antibodies testcreative-biolabs.com has been visited by 10K+ users in the past month