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Estradiol cypionate (Depo-Estradiol, Estradiol Cypionate) – 5 mg/mL (1 mg/mL and 3 mg/mL discontinued) Estradiol valerate (Delestrogen, Estradiol Valerate) – 10 mg/mL, 20 mg/mL, 40 mg/mL; Polyestradiol phosphate (Estradurin) was previously available in the U.S. but was discontinued.
Estradiol-containing birth control pills were initially studied in the 1970s, with the first report published in 1977. [230] [231] Development of birth control pills containing estradiol was motivated by the thrombotic risks of ethinylestradiol that were uncovered in the 1960s and 1970s.
Estradiol-containing birth control pills, which contain 1 to 3 mg/day estradiol or estradiol valerate, have been found to increase sex hormone-binding globulin (SHBG) levels by 1.5-fold. [ 101 ] [ 102 ] Oral estradiol valerate at 6 mg/day has been found to increase SHBG levels by 2.5- to 3-fold in transgender women .
How much will Opill cost? Opill has a suggested retail price of $19.99 for a one-month supply. If you want to stock up with a three-month supply, you’ll spend around $50, Perrigo says.
The risk of VTE with estradiol/nomegestrol acetate birth control pills is under study. [11] Incidence of irregular vaginal bleeding may be higher with estradiol-containing birth control pills in relation to the fact that estradiol is a weaker estrogen than ethinylestradiol in the endometrium. [3]
Country Region Availability Over the counter Non-prescription Age restriction Cost Awareness Notes Afghanistan: Asia: Import only [2]Albania: Europe: None [3]: €15,60 (UPA)
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