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The first version of the rules applied to all women with high testosterone, but the current version of the rules only apply to athletes with certain XY disorders of sexual development, and set a 5 nmol/L testosterone limit, which applies only to distances between 400 m and 1 mile (inclusive), other events being unrestricted.
The use of high-dose estrogen therapy in breast cancer has mostly been superseded by antiestrogen therapy due to the improved safety profile of the latter. [17] High-dose estrogen therapy was the standard of care for the palliative treatment of breast cancer in women up to the late 1970s or early 1980s. [18
A study that used high- to very-high-dose oral estradiol to treat postmenopausal women with estrogen receptor-positive breast cancer found that mean steady-state estradiol levels in the 6 mg/day group were about 300 pg/mL and in the 30 mg/day group were about 2,400 pg/mL. [37]
Similarly, there appears to be little or no relationship between total or free testosterone levels in the normal physiological range and sexual desire in premenopausal women. [41] [40] Only high doses of testosterone resulting in supraphysiological levels of testosterone (>50 ng/dL) significantly increase sexual desire in women, with levels of ...
In dose-ranging studies, tamoxifen was administered at very high doses in women (e.g., 300 mg/m 2) and was found to produce acute neurotoxicity including tremor, hyperreflexia, unsteady gait, and dizziness. [12] These symptoms occurred within three to five days of therapy and disappeared within two to five days of discontinuation of therapy. [12]
A large clinical study of high to very high oral dosages of norethisterone (10 to 40 mg/day) administered for prolonged periods of time (4 to 35 weeks) to prevent miscarriage in pregnant women found that 5.5% of the women experienced mild androgenic side effects such as mild voice changes , acne, and hirsutism and that 18.3% of female infants ...
A new trend gaining popularity among people trying to lose weight is microdosing the diabetes medication Ozempic. With approximately 70% of American adults meeting the criteria for being obese or ...
Drostanolone propionate produces considerably less virilization in women compared to equal doses of testosterone propionate. [1] However, since the given dosage for breast cancer was relatively high (200 mg/twice a week), [ 8 ] mild virilization including oily skin , acne , voice deepening , hirsutism , and clitoral enlargement could still ...