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Tissue reactions include skin reactions (epilation, erythema, moist desquamation), cataracts, circulatory disease, and other conditions. Seven proteins were discovered in a systematic review, which correlated with radiosensitivity in normal tissues: γH2AX, TP53BP1, VEGFA, CASP3, CDKN2A, IL6, and IL1B.
The oxygen effect has particular importance in external beam radiation therapy where the killing of tumour cells with photon and electron beams in well oxygenated regions can be up to three times greater than in a poorly vasculated portion of the tumour.
The four trials are a Phase II/III in soft tissue sarcoma of the extremity and trunk wall, [9] a Phase I/II for hepatocellular carcinoma, [10] a Phase I/II for prostate cancer, [11] and a Phase I for squamous cell carcinoma of the oral cavity. [12] Nimoral Azanta This compound increases the yield of DNA damage from irradiation under hypoxic ...
Many research papers have been published investigating whether FLASH RT creates a hypoxic environment in healthy tissue, which makes it less radiosensitive. The oxygen depletion was thought to be caused by radiolysis of water molecules, where water breaks down into hydrogen peroxide , hydrogen radicals and other oxygen compounds.
Radiation-induced lung injury (RILI) is a general term for damage to the lungs as a result of exposure to ionizing radiation. [1] In general terms, such damage is divided into early inflammatory damage (radiation pneumonitis) and later complications of chronic scarring (radiation fibrosis).
Radiation treatments may damage nerves near the target area or within the delivery path as nerve tissue is also radiosensitive. [41] Nerve damage from ionizing radiation occurs in phases, the initial phase from microvascular injury, capillary damage and nerve demyelination. [42]
The treatment's ionizing radiation is an activation mechanism for apoptosis (cell death) within the targeted cancer, [13] but it can also impact nearby healthy radiosensitive tissues, like the lumbosacral plexus.
Radioresistance is the level of ionizing radiation that organisms are able to withstand.. Ionizing-radiation-resistant organisms (IRRO) were defined as organisms for which the dose of acute ionizing radiation (IR) required to achieve 90% reduction (D10) is greater than 1,000 gray (Gy) [1]