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Cells are least sensitive when in the S phase, then the G 1 phase, then the G 2 phase, and most sensitive in the M phase of the cell cycle.This is described by the 'law of Bergonié and Tribondeau', formulated in 1906: X-rays are more effective on cells which have a greater reproductive activity.
Conventional chemotherapeutics are currently being used in conjunction with radiation therapy to increase its effectiveness. Examples include the fluoropyrimidines, gemcitabine and platinum analogs; fluoropyrimidines increase sensitivity by dysregulating S-phase cell cycle checkpoints in tumor cells.
Radiation sensitivity is the susceptibility of a material to physical or chemical changes induced by radiation. [1] Examples of radiation sensitive materials are silver chloride, photoresists and biomaterials.
The oxygen effect has particular importance in external beam radiation therapy where the killing of tumour cells with photon and electron beams in well oxygenated regions can be up to three times greater than in a poorly vasculated portion of the tumour.
Highly radiosensitive cancer cells are rapidly killed by modest doses of radiation. These include leukemias, most lymphomas, and germ cell tumors. The majority of epithelial cancers are only moderately radiosensitive, and require a significantly higher dose of radiation (60–70 Gy) to achieve a radical cure. Some types of cancer are notably ...
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The suspect in the truck attack that killed 14 and injured dozens in New Orleans on New Year's had traveled to Egypt in 2023 for about a month, his half-brother told ABC News. Shamsud-Din Jabbar ...
In general, cells are most radiosensitive in late M and G 2 phases and most resistant in late S phase. For cells with a longer cell cycle time and a significantly long G 1 phase, there is a second peak of resistance late in G 1. The pattern of resistance and sensitivity correlates with the level of sulfhydryl compounds in the cell.