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Thus, the Haldane effect describes the ability of hemoglobin to carry increased amounts of carbon dioxide (CO 2) in the deoxygenated state as opposed to the oxygenated state. Vice versa, it is true that a high concentration of CO 2 facilitates dissociation of oxyhemoglobin, though this is the result of two distinct processes (Bohr effect and ...
The Haldane effect: most carbon dioxide is carried by the blood as bicarbonate, and deoxygenated hemoglobin promotes the production of bicarbonate. Increasing the amount of oxygen in the blood by administering supplemental oxygen reduces the amount of deoxygenated hemoglobin, and thus reduces the capacity of blood to carry carbon dioxide.
Enzymes however display a saturation effect where,, as the substrate concentration is increased the reaction rate reaches a maximum value. Standard approaches to describing this behavior are based on models developed by Michaelis and Menten as well and Briggs and Haldane. Most elementary formulations of these models assume that the enzyme ...
The opposite process occurs in the pulmonary capillaries of the lungs when the PO 2 rises and PCO 2 falls, and the Haldane effect occurs (release of CO 2 from hemoglobin during oxygenation). This releases hydrogen ions from hemoglobin, increases free H + concentration within RBCs, and shifts the equilibrium towards CO 2 and water formation from ...
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While inhaling air is critical to supply cells with oxygen for aerobic respiration via the Bohr effect and Haldane effect (and perhaps local low oxygen partial pressure e.g. active muscles), [32] exhaling the cellular waste product carbon dioxide is arguably the more critical aspect of respiration.
The first Decompression tables: John Scott Haldane (1908); to calculate the safe return of deep-sea divers to surface atmospheric pressure [151] Oxygen therapy: John Scott Haldane (1922), with the publication of ‘The Therapeutic Administration of Oxygen Therapy’, beginning the modern era of Oxygen therapy [152]