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An antigen-presenting cell (APC) or accessory cell is a cell that displays an antigen bound by major histocompatibility complex (MHC) proteins on its surface; this process is known as antigen presentation. T cells may recognize these complexes using their T cell receptors (TCRs). APCs process antigens and present them to T cells.
Later research showed that B cell activation is reliant on CD4+ T helper cells and a co-stimulatory signal from an antigen-presenting cell (APC). Because APCs are not antigen -specific, capable of processing self structures, Charles Janeway proposed the Infectious Non-self Model in 1989. [ 3 ]
[6] [8] The APC Activator IMP321 (Eftilagimod alpha), a soluble LAG-3 fusion protein, is currently undergoing clinical trials in combination with chemotherapy , or immune checkpoint inhibitors, including the PD-1 monoclonal antibody pembrolizumab, to accelerate the adaptive immune response in several tumor indications. [9] [2] [4]
n/a Ensembl n/a n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a Wikidata View/Edit Human T cell receptor gamma locus is a protein that in humans is encoded by the TRG gene, also known as TCRG or TRG@. It contributes the gamma (γ) chain to the larger TCR protein (T-cell receptor). Function T cell receptors recognize foreign antigens ...
Anaphase-promoting complex (also called the cyclosome or APC/C) is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin and RING subunit much like SCF.
His works have been published in academic journals, including American Journal of Tropical Medicine and Hygiene, Parasitology Research, Frontiers in Microbiology, and Heliyon. [2] Additionally, he was listed among the top 2% of the World's Researchers in 2020 and 2023 and top 100 Scientists of Asia in 2017.
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Canadian Journal of Infectious Diseases & Medical Microbiology: Infectious Disease: Pulsus Group: English: 1990–present Canadian Medical Association Journal: Medicine: Canadian Medical Association: English, French: 1911–present Canadian Respiratory Journal: Respiratory Health: Pulsus Group: English, French: 1994–present Cancer Medicine ...