Search results
Results from the WOW.Com Content Network
Sodium thiosulfate, also spelled sodium thiosulphate, is used as a medication to treat cyanide poisoning, pityriasis versicolor, and to decrease side effects from cisplatin. [ 3 ] [ 4 ] [ 5 ] For cyanide poisoning, it is often used after the medication sodium nitrite and is typically only recommended for severe cases.
Thiosulfate: The evidence for sodium thiosulfate's use is based on animal studies and case reports: the small quantities of cyanide present in dietary sources and in cigarette smoke are normally metabolized to relatively harmless thiocyanate by the mitochondrial enzyme rhodanese (thiosulfate cyanide sulfurtransferase), which uses thiosulfate as ...
The three parts are amyl nitrite, sodium nitrite, and sodium thiosulfate. [3] The nitrites act with hemoglobin to form methemoglobin which binds cyanide. Cyanide has a preference to the ferric ion on methemoglobin over the ferric ion on cytochrome oxidase a 3 and causes cyanide to be drawn out of the mitochondria. This causes the mitochondria ...
Sodium thiosulfate (sodium thiosulphate) is an inorganic compound with the formula Na 2 S 2 O 3 ·(H 2 O) x. Typically it is available as the white or colorless pentahydrate (x = 5), which is a white solid that dissolves well in water. The compound is a reducing agent and a ligand, and these properties underpin its applications. [2]
Sodium thiosulfate has been considered as an empirical treatment for cyanide poisoning, along with hydroxocobalamin. It is most effective in a pre-hospital setting, since immediate administration by emergency personnel is necessary to reverse rapid intracellular hypoxia caused by the inhibition of cellular respiration, at complex IV. [6] [7] [8 ...
Calcium channel blocker toxicity, [7] hydrofluoric acid burns Chelators such as EDTA, dimercaprol (BAL), penicillamine, and 2,3-dimercaptosuccinic acid (DMSA, succimer) Heavy metal poisoning: Cyanide antidotes (hydroxocobalamin, amyl nitrite, sodium nitrite, or thiosulfate) Cyanide poisoning: Cyproheptadine: Serotonin syndrome: Deferoxamine ...
Remember the four P's when dealing with cold: Pets, Pipes, Plants and People (elderly and young). Bring pets inside and make sure they have plenty of food and water as well.
Deliberate cyanide poisoning of humans has occurred many times throughout history. [44] Common salts such as sodium cyanide are involatile but water-soluble, so are poisonous by ingestion. Hydrogen cyanide is a gas, making it more indiscriminately dangerous, however it is lighter than air and rapidly disperses up into the atmosphere, which ...