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The WHO recommends childhood BCG for all countries with a high incidence of tuberculosis and/or high leprosy burden. [9] This is a partial list of historic and active BCG practices around the globe. A complete atlas of past and present practice has been generated. [50] As of 2022, 155 countries offer the BCG vaccine in their schedule. [51]
Prevention of TB involves screening those at high risk, early detection and treatment of cases, and vaccination with the bacillus Calmette-Guérin (BCG) vaccine. [3] [4] [5] Those at high risk include household, workplace, and social contacts of people with active TB. [4] Treatment requires the use of multiple antibiotics over a long period of ...
Tuberculosis (TB) vaccines are vaccinations intended for the prevention of tuberculosis. Immunotherapy as a defence against TB was first proposed in 1890 by Robert Koch . [ 1 ] As of 2021, the only effective tuberculosis vaccine in common use is the Bacillus Calmette-Guérin (BCG) vaccine, first used on humans in 1921.
The Stop TB Initiative was established following the meeting of the First Session of the Ad Hoc Committee on the Tuberculosis Epidemic held in London in March 1998. [4] In March 2000 the Stop TB Partnership produced the Amsterdam Declaration to Stop TB, which called for action from ministerial delegations of 20 countries with the highest burden of TB.
The true scale of XDR-TB is unknown as many countries lack the necessary equipment and capacity to accurately diagnose it. By June 2008, 49 countries had confirmed cases of XDR-TB. [3] By the end of 2017, 127 WHO Member States reported a total of 10,800 cases of XDR-TB, and 8.5% of cases of MDR-TB in 2017 were estimated to have been XDR-TB. [2]
The goal of tuberculosis elimination is hampered by the lack of rapid testing, short and effective treatment courses, and completely effective vaccine. [2] The WHO as well as the Stop TB Partnership aim for the full elimination of TB by 2050—requiring a 1000-fold reduction in tuberculosis incidence. [ 3 ]
Scanning electron micrograph of Mycobacterium tuberculosis. Tuberculosis is a serious public health problem in China. [1] China has the world's third largest cases of tuberculosis (after India and Indonesia), but progress in tuberculosis control was slow during the 1990s.
The risk of developing TB is estimated to be between 20 and 37 times greater in people living with HIV than among those without HIV infection. TB is a leading cause of morbidity and mortality among people living with HIV. [13] In 2009, there were 9.4 million new cases of TB, of which 1.2 (13%) million were among people living with HIV.