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Time-resolved RNA sequencing methods are applications of RNA-seq that allow for observations of RNA abundances over time in a biological sample or samples. Second-Generation DNA sequencing has enabled cost effective, high throughput and unbiased analysis of the transcriptome . [ 1 ]
During this time, development focused on the time-series-oriented database engine and the 4GL scripting language. Citigroup sold FAME to private investors headed by Warburg Pincus in 1994. Management focused on fixing bugs , developing remote database server access to FAME, and investing in expanding the FAME database engine.
A time series database is a software system that is optimized for storing and serving time series through associated pairs of time(s) and value(s). [1] In some fields, time series may be called profiles, curves, traces or trends. [ 2 ]
The word transcriptome is a portmanteau of the words transcript and genome.It appeared along with other neologisms formed using the suffixes -ome and -omics to denote all studies conducted on a genome-wide scale in the fields of life sciences and technology.
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The word "transcriptome" was first used in the 1990s. [19] [20] In 1995, one of the earliest sequencing-based transcriptomic methods was developed, serial analysis of gene expression (SAGE), which worked by Sanger sequencing of concatenated random transcript fragments. [21] Transcripts were quantified by matching the fragments to known genes.
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