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  2. meta-Chlorophenylpiperazine - Wikipedia

    en.wikipedia.org/wiki/Meta-Chlorophenylpiperazine

    [2] [51] [52] The elimination half-life of mCPP is 4 to 14 hours. [2] mCPP is a metabolite of a variety of other piperazine drugs including trazodone, nefazodone, etoperidone, enpiprazole, mepiprazole, cloperidone, peraclopone, and BRL-15,572. [52] [additional citation(s) needed] It is formed by dealkylation via CYP3A4. [52]

  3. Trazodone - Wikipedia

    en.wikipedia.org/wiki/Trazodone

    Trazodone has a minor active metabolite known as meta-chlorophenylpiperazine (mCPP), and this metabolite may contribute to some degree to the pharmacological properties of trazodone. [11] [110] In contrast to trazodone, mCPP is an agonist of various serotonin receptors. [111]

  4. Substituted piperazine - Wikipedia

    en.wikipedia.org/wiki/Substituted_piperazine

    Trazodone, nefazodone, mepiprazole, and others produce mCPP as a metabolite. para-Substituted. 4-Chlorophenylpiperazine (pCPP) 4-Fluorophenylpiperazine (pFPP)

  5. Serotonin antagonist and reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/Serotonin_antagonist_and...

    These drugs act as antagonists or inverse agonists of the 5-HT 2A, α 1-adrenergic, and H 1 receptors, as partial agonists of the 5-HT 1A receptor, [3] and as inhibitors of the transporters. mCPP is an antagonist of the 5-HT 2B receptor, an agonist of the 5-HT 1A, [3] 5-HT 2C, and 5-HT 3 receptors, [4] [5] and acts as a partial agonist of the ...

  6. The 3 Most Overpriced Cities in America, According to Gen Z ...

    www.aol.com/3-most-overpriced-cities-america...

    Here, the median home size for October listings was 1,749 square feet, and the sale price was $712 per square foot. Approximately 29% of 25- to 34-year olds called LA overpriced in the survey.

  7. Complete college football bowl schedule for 2024-25: Games ...

    www.aol.com/sports/college-football-bowl...

    Welcome to bowl season! From the IS4S Salute to Veterans Bowl on Dec. 14 to the College Football Playoff National Championship Game on Jan. 20, 82 teams will play in at least one postseason game.

  8. A Cold War-era bomb shelter in Florida has new owners. What's ...

    www.aol.com/cold-war-era-bomb-shelter-100924902.html

    Hoyt C. "Pat" Murphy, Jr., of Coldwell Banker Paradise Hoyt Murphy Realtors, crawls through a square hatch that leads to a pair of ventilation intake shafts while touring a Cold War-era bomb ...

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