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[2] [51] [52] The elimination half-life of mCPP is 4 to 14 hours. [2] mCPP is a metabolite of a variety of other piperazine drugs including trazodone, nefazodone, etoperidone, enpiprazole, mepiprazole, cloperidone, peraclopone, and BRL-15,572. [52] [additional citation(s) needed] It is formed by dealkylation via CYP3A4. [52]
Trazodone has a minor active metabolite known as meta-chlorophenylpiperazine (mCPP), and this metabolite may contribute to some degree to the pharmacological properties of trazodone. [11] [110] In contrast to trazodone, mCPP is an agonist of various serotonin receptors. [111]
Trazodone, nefazodone, mepiprazole, and others produce mCPP as a metabolite. para-Substituted. 4-Chlorophenylpiperazine (pCPP) 4-Fluorophenylpiperazine (pFPP)
These drugs act as antagonists or inverse agonists of the 5-HT 2A, α 1-adrenergic, and H 1 receptors, as partial agonists of the 5-HT 1A receptor, [3] and as inhibitors of the transporters. mCPP is an antagonist of the 5-HT 2B receptor, an agonist of the 5-HT 1A, [3] 5-HT 2C, and 5-HT 3 receptors, [4] [5] and acts as a partial agonist of the ...
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Welcome to bowl season! From the IS4S Salute to Veterans Bowl on Dec. 14 to the College Football Playoff National Championship Game on Jan. 20, 82 teams will play in at least one postseason game.
Hoyt C. "Pat" Murphy, Jr., of Coldwell Banker Paradise Hoyt Murphy Realtors, crawls through a square hatch that leads to a pair of ventilation intake shafts while touring a Cold War-era bomb ...
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