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The Stork enamine synthesis: formation of an enamine from a ketone; addition of the enamine to an alpha, beta-unsaturated aldehyde or ketone; hydrolysis of the enamine back to a ketone; The Stork enamine reaction. The reaction also applies to acyl halides as electrophiles, which results in the formation of 1,3-diketones (Stork acylation). [2]
In a reaction much similar to the enamine alkylation, enamines can be acylated to form a final dicarbonyl product. The enamine starting material undergoes a nucleophilic addition to acyl halides forming the iminium salt intermediate which can hydrolyze in the presence of acid. [16] Enamine nucleophile attacks acetyl chloride to form a ...
Amine alkylation (amino-dehalogenation) is a type of organic reaction between an alkyl halide and ammonia or an amine. [1] The reaction is called nucleophilic aliphatic substitution (of the halide), and the reaction product is a higher substituted amine. The method is widely used in the laboratory, but less so industrially, where alcohols are ...
Amine alkylation; Angeli–Rimini reaction; Andrussov oxidation; Appel reaction; ... Stork enamine alkylation; Strecker amino acid synthesis; Strecker degradation;
The likely reaction mechanism for the Kindler modification. The first stage of the reaction is basic imine formation by the ketone group and the amine group of morpholine to give an enamine . This reacts as a nucleophile with electrophilic sulfur, similar to an Stork enamine alkylation reaction.
In organic chemistry, the Mannich reaction is a three-component organic reaction that involves the amino alkylation of an acidic proton next to a carbonyl (C=O) functional group by formaldehyde (H−CHO) and a primary or secondary amine (−NH 2) or ammonia (NH 3). [1]
In the episode, Stamos said he was unable to continue going for the iconic role in the adaptation of Dr. Seuss' 1957 children's book because he had an allergic reaction to the prosthetics during a ...
Enamines derived from piperidine are substrates in the Stork enamine alkylation reaction. [24] Upon treatment with calcium hypochlorite, piperidine converts to N-chloropiperidine, a chloramine with the formula C 5 H 10 NCl. The resulting chloramine undergoes dehydrohalogenation to afford the cyclic imine. [25]