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In a suspected antiphospholipid syndrome, lupus anticoagulant is generally tested in conjunction with anti-apolipoprotein antibodies and anti-cardiolipin antibodies, and diagnostic criteria require one clinical event (i.e. thrombosis or pregnancy complication) and two positive blood test results spaced at least three months apart that detect at ...
Anti-Ro/SSA antibodies are found in 40–90% of patients with systematic lupus erythematosus (SLE). The antibodies can be detected years before symptoms of SLE surface, making them an effective diagnostic tool. [3] [9] In patients with SLE, high levels of Anti-Ro/SSA are correlated with elevated levels of IFN-α.
Ninety-six percent of patients with lupus induced by procainamide will have a positive test for anti-histone antibodies, and 100% of patients whose lupus was induced by penicillamine, isoniazid, or methyldopa will have a positive test for anti-histone antibodies. In 70% of patients with rheumatoid arthritis, Felty's syndrome, Sjogren's syndrome ...
Immunological criteria: Individuals exhibiting 1) high serum levels of antinuclear antibodies; 2) high serum levels of anti-dsDNA antibodies; 3) high serum levels of anti-Sm antibodies; 4) high blood levels of antiphospholipid antibodies, high blood levels of the lupus anticoagulant, a false positive rapid plasma reagin test, or a medium to ...
Coeliac disease (antibody levels correlate with the level of intestinal damage [8] [9]), autoimmune hepatitis, gastric cancer: anti-CCP: cyclic citrullinated peptide: rheumatoid arthritis: Liver kidney microsomal type 1 antibody: autoimmune hepatitis [10] Lupus anticoagulant: Anti-thrombin antibodies: thrombin: systemic lupus erythematosus ...
Therefore, presence of anti-dsDNA antibodies are suggestive of SLE, however an absence of the antibodies does not rule out the disease. [1] The levels of circulating anti-dsDNA antibodies fluctuate with disease activity in SLE. Increases in titres of the antibodies can coincide with, or even precede an increase of disease activity.
Data on sensitivity ranges from 25 to 85%. Anti-dsDNA antibody levels, known as titres, correlate with disease activity in SLE; high levels indicate more active lupus. The presence of anti-dsDNA antibodies is also linked with lupus nephritis and there is evidence they are the cause.
Fresh normal plasma has all the blood coagulation factors with normal levels. If the problem is a simple factor deficiency, mixing the patient plasma 1:1 with plasma that contains 100% of the normal factor level results in a level ≥50% in the mixture (say the patient has an activity of 0%; the average of 100% + 0% = 50%). [3]