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Cocaine was first used as a local anesthetic in 1884. The search for a less toxic and less addictive substitute led to the development of the aminoester local anesthetics stovaine in 1903 and procaine in 1904. Since then, several synthetic local anesthetic drugs have been developed and put into clinical use, notably lidocaine in 1943 ...
A local anesthetic is a drug that causes reversible local anesthesia and a loss of nociception.When it is used on specific nerve pathways (nerve block), effects such as analgesia (loss of pain sensation) and paralysis (loss of muscle power) can be achieved.
Local anesthetic injections are given in specific areas of the mouth, rather than the whole body. Although several different medications are available, the most commonly used local anesthetic to prevent pain in the area around a tooth is lidocaine (also called xylocaine or lignocaine). Lidocaine's half-life in the body is about 1.5–2 hours. [2]
This is a list of local anesthetic agents. Not all of these drugs are still used in clinical practice and in research. Some are primarily of historical interest.
Leaves of the coca plant (Erythroxylum novogranatense var. Novogranatense), from which cocaine, a naturally occurring local anesthetic, is derived [1] [2]. An anesthetic (American English) or anaesthetic (British English; see spelling differences) is a drug used to induce anesthesia — in other words, to result in a temporary loss of sensation or awareness.
The most common local anesthetics used at the site of the nerves are bupivicaine, mepivicaine, and chloroprocaine. [48] There is a very high chance that the phrenic nerve , which innervates the diaphragm , will be blocked so this block should only be done on patients who have use of their accessory respiratory muscles. [ 48 ]
Articaine is a dental amide-type local anesthetic. It is the most widely used local anesthetic in a number of European countries [2] and is available in many countries. It is the only local anaesthetic to contain a thiophene ring, meaning it can be described as 'thiophenic'; this conveys lipid solubility. [3]
Pudendal anesthesia (pudendal nerve block, pudendal block or saddle block) is a form of local anesthesia. Pudendal anesthesia can be used to diagnose as well as treat illnesses. [ 1 ] A nerve block is the use of local anesthetic (e.g lidocaine ) to inhibit the sensation of pain caused by one or multiple nerves. [ 2 ]