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Side effects include irregular periods, benign ovarian cysts, pelvic pain, and depression. [2] Rarely uterine perforation may occur. [2] Use is not recommended during pregnancy but is safe with breastfeeding. [2] The IUD with progestogen is a type of long-acting reversible birth control. [5]
[49] [2] A review indicated the usefulness of using calcium channel blockers. [32] Heat is effective compared to NSAIDs and is a preferred option by many patients, as it is easy to access and has no known side effects. [50] Tamoxifen has been used effectively to reduce uterine contractility and pain in dysmenorrhea patients. [51]
A 2010 Cochrane review found that GnRH modulators were more effective for pain relief in endometriosis than no treatment or placebo, but were not more effective than danazol or intrauterine progestogen, and had more side effects than danazol. [151]
Different sources note different incidence of side effects. The most common side effect is breakthrough bleeding. Combined oral contraceptive pills can improve conditions such as dysmenorrhea, premenstrual syndrome, and acne, [105] reduce symptoms of endometriosis and polycystic ovary syndrome, and decrease the risk of anemia. [106]
Hormonal therapies to reduce or stop menstrual bleeding have long been used to manage a number of gynecologic conditions including menstrual cramps (dysmenorrhea), heavy menstrual bleeding, irregular or other abnormal uterine bleeding, menstrual-related mood changes (premenstrual syndrome or premenstrual dysphoric disorder), and pelvic pain due to endometriosis or uterine fibroids.
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