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A protein kinase inhibitor (PKI) is a type of enzyme inhibitor that blocks the action of one or more protein kinases. Protein kinases are enzymes that phosphorylate (add a phosphate, or PO 4, group) to a protein and can modulate its function. The phosphate groups are usually added to serine, threonine, or tyrosine amino acids on the protein.
cAMP-dependent protein kinase inhibitor alpha is a protein that in humans is encoded by the PKIA gene. [5] [6] The protein encoded by this gene is a member of the cAMP-dependent protein kinase inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA.
p21 is a potent cyclin-dependent kinase inhibitor (CKI). The p21 (CIP1/WAF1) protein binds to and inhibits the activity of cyclin-CDK2, -CDK1, and -CDK4 /6 complexes, and thus functions as a regulator of cell cycle progression at G 1 and S phase.
1027 12576 Ensembl ENSG00000111276 ENSMUSG00000003031 UniProt P46527 P46414 RefSeq (mRNA) NM_004064 NM_009875 RefSeq (protein) NP_004055 NP_034005 Location (UCSC) Chr 12: 12.69 – 12.72 Mb Chr 6: 134.9 – 134.9 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cyclin-dependent kinase inhibitor 1B (p27 Kip1) is an enzyme inhibitor that in humans is encoded by the CDKN1B gene. It ...
BIM-1 is present in the structure of PKCiota [3] (residue 574-turn [4] motif). It needs to be phosphorylated towards a PKCbeta-specific inhibitor site-directed mutagenesis of the compound for its full activation [5] and co-crystallized as an asymmetric pair which is mediated by 3-phosphoinositide-dependent protein kinase-1 [6] are downstream characteristics of PKCs and PKB/AKT.
Pages in category "Protein kinase inhibitors" The following 62 pages are in this category, out of 62 total. This list may not reflect recent changes. ...
CDKN2A, also known as cyclin-dependent kinase inhibitor 2A, is a gene which in humans is located at chromosome 9, band p21.3. [5] It is ubiquitously expressed in many tissues and cell types. [ 6 ] The gene codes for two proteins , including the INK4 family member p16 (or p16INK4a) and p14arf . [ 7 ]
A cyclin-dependent kinase inhibitor protein (also known as CKIs, CDIs, or CDKIs) is a protein that inhibits the enzyme cyclin-dependent kinase (CDK) and Cyclin activity by stopping the cell cycle if there are unfavorable conditions, therefore, acting as tumor suppressors.