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The Lille Model is a medical modeling tool for predicting mortality in patients with alcoholic hepatitis who are not responding to steroid therapy. The model risk stratifies patients who have been receiving steroid treatment for seven days to predict who will improve and who should be considered for alternative treatment options including early referral for transplant.
In 2016, an updated PROMIS website at www.HealthMeasures.net was created to provide more information about measure selection, data collection tools, score calculation, score interpretation, item response theory, and support an online forum for posting questions to the PROMIS user community. [10]
Simple to calculate: In simple cases, manual computing can be used to calculate a basic score (although some scores use rely on more sophisticated or less transparent calculations that require a computer program). Easily interpreted: The result of the calculation is a single number, with a higher score usually means higher risk.
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[1] [2] Each item on the scale is scored independently, and the summation of the scores yields an aggregate value that correlates to the severity of alcohol withdrawal, with ranges of scores designed to prompt specific management decisions such as the administration of benzodiazepines. The maximum score is 67; Mild alcohol withdrawal is defined ...
A score of zero means that no comorbidities were found; the higher the score, the higher the predicted mortality rate is. [2] [3] For a physician, this score is helpful in deciding how aggressively to treat a condition. It is one of the most widely used scoring system for comorbidities. [4]
NRI attempts to quantify how well a new model correctly reclassifies subjects. Typically this comparison is between an original model (e.g. hip fractures as a function age and sex) and a new model which is the original model plus one additional component (e.g. hip fractures as a function of age, sex, and a genetic or proteomic biomarker).
Nonetheless, it has many criticisms, [5] including the fact that it has moderate intra-rater reliability (EDSS kappa values between 0.32 and 0.76 and between 0.23 and 0.58 for the individual FSs were reported), offers poor assessment of upper limb and cognitive function, and lacks linearity between score difference and clinical severity. Other ...