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Fetal programming, also known as prenatal programming, is the theory that environmental cues experienced during fetal development play a seminal role in determining health trajectories across the lifespan. Three main forms of programming that occur due to changes in the maternal environment are:
The fetal adrenal cortex can be identified within four weeks of pregnancy. [2] The adrenal cortex originates from the thickening of the intermediate mesoderm . [ 3 ] At five to six weeks of gestation, the mesonephros differentiates into a tissue known as the gonadal ridge.
This response mechanism plays a crucial role in male sexual differentiation and puberty, as well as other tissue types and processes, such as the prostate gland (regulate secretory functions), hair follicles (androgens influence hair growth patterns), skin (androgens regulate sebum production and the thickening and maturation of the skin), and ...
One theory is that high progesterone levels act as an antagonist to the cortisol. The adrenal gland also produces more aldosterone , leading to an eight-fold increase in aldosterone. [ 5 ] Women do not show signs of hyperaldosterone, such as hypokalemia, hypernatremia, or high blood pressure.
The fetal origins hypothesis (differentiated from the Developmental Origins of Health and Disease hypothesis, which emphasizes environmental conditions both before and immediately after birth) proposes that the period of gestation has significant impacts on the developmental health and wellbeing outcomes for an individual ranging from infancy to adulthood.
Levels rise towards the end of pregnancy just before birth and current theory suggests three roles of CRH in parturition: [27] Increases levels of dehydroepiandrosterone (DHEA) directly by action on the fetal adrenal gland, and indirectly via the mother's pituitary gland. DHEA has a role in preparing for and stimulating cervical contractions.
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The fetal adrenal cortex can be identified within four weeks of gestation. The adrenal cortex originates from the thickening of the intermediate mesoderm. At five to six weeks of gestation, the mesonephros differentiates into a tissue known as the genital ridge. The genital ridge produces the steroidogenic cells for both the gonads and the ...