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From 1996 to 2012, under the trade name Lipitor, atorvastatin became the world's best-selling medication of all time, with more than $125 billion in sales over approximately 14.5 years. [116] and $13 billion a year at its peak, [117] Lipitor alone "provided up to a quarter of Pfizer Inc.'s annual revenue for years." [116]
The symptoms experienced in cholesterol embolism depend largely on the organ involved. Non-specific symptoms often described are fever, muscle ache and weight loss.Embolism to the legs causes a mottled appearance and purple discoloration of the toes, small infarcts and areas of gangrene due to tissue death that usually appear black, and areas of the skin that assume a marbled pattern known as ...
[5] [65] Over 5 years of treatment statins result in 75 cases of diabetes, 7.5 cases of bleeding stroke, and 5 cases of muscle damage per 10,000 people treated. [34] This could be due to the statins inhibiting the enzyme (HMG-CoA reductase), which is necessary to make cholesterol, but also for other processes, such as CoQ 10 production, which ...
Globally, it causes about 10 million deaths per year. Atherosclerosis is characterized by the build-up of plaque inside your blood vessels. It can lead to stenosis, which is a narrowing of your ...
Based on their analyses, they found that many of the examined medications decreased the risk of dementia if taken for 5 years or longer. They found this true for antihypertensives, lipid-lowering ...
The most common causes of CKD are high blood pressure and diabetes, "which damage the small blood vessels and filtering units in the kidneys over time," says Nagata. Other potential causes he ...
Hypercholesterolemia, also called high cholesterol, is the presence of high levels of cholesterol in the blood. [1] It is a form of hyperlipidemia (high levels of lipids in the blood), hyperlipoproteinemia (high levels of lipoproteins in the blood), and dyslipidemia (any abnormalities of lipid and lipoprotein levels in the blood).
The average age for perimenopause in the U.S. is around 47 years old, and while the average duration of perimenopause is four years, it can range from eight to 10, according to the Cleveland ...
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