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Wernicke encephalopathy (WE), also Wernicke's encephalopathy, [1] or wet brain is the presence of neurological symptoms caused by biochemical lesions of the central nervous system after exhaustion of B-vitamin reserves, in particular thiamine (vitamin B 1). [2]
In individuals with sub-clinical thiamine deficiency, a large dose of glucose (either as sweet food or glucose infusion) can precipitate the onset of overt encephalopathy. [ 16 ] [ 17 ] [ 18 ] Wernicke-Korsakoff syndrome in people with chronic alcohol use particularly is associated with atrophy / infarction of specific regions of the brain ...
Korsakoff syndrome (KS) [1] is a disorder of the central nervous system characterized by amnesia, deficits in explicit memory, and confabulation.This neurological disorder is caused by a deficiency of thiamine (vitamin B 1) in the brain, and it is typically associated with and exacerbated by the prolonged, excessive ingestion of alcohol. [2]
Vitamin B 1 analogues are analogues of vitamin B 1, thiamine. They typically have improved bioavailability relative to thiamine itself, and are used to treat conditions caused by vitamin B 1 deficiency. These conditions include beriberi, Korsakoff's syndrome, Wernicke's encephalopathy and diabetic neuropathy.
Wernicke syndrome is an ambiguous term. It may refer to: Wernicke aphasia: the eponymous term for receptive or sensory aphasia.; Wernicke encephalopathy: an acute neurological syndrome of ophthalmoparesis, ataxia, and encephalopathy brought on by thiamine deficiency.
To help to prevent Wernicke syndrome, these individuals should be administered a multivitamin preparation with sufficient quantities of thiamine and folic acid. During alcohol withdrawal, the prophylactic administration of thiamine, folic acid, and pyridoxine intravenously is recommended before starting any carbohydrate-containing fluids or food.
Lower brain oxygen levels caused by sleep apnea were linked to changes to the white matter, which could lead to cognitive problem, a new study suggests.
Thiamine is effective for treatment of Wernicke–Korsakoff syndrome as well as ethylene glycol ingestion. For ethylene glycol, thiamine helps by preventing synthesis of the glycol's metabolites. Overall, thiamine does not cause as notable issues in the cocktail, but patients can be sensitive to it nonetheless.