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According to a 2015 review article, Lewis lung carcinoma is the only reproducable syngeneic lung cancer model, meaning that it is the only reproducible lung cancer model that utilizes a transplant that is immunologically compatible. Syngeneic models have proven to be useful in predicting clinical benefit of therapy in preclinical experiments.
The laboratory mouse has physiology and genetic characteristics very similar to humans providing powerful models for investigation of the genetic characteristics of disease. [ 2 ] The Mouse Models of Human Cancer database (MMHCdb) is a unique, comprehensive online knowledgebase of mouse models of human cancer hosted by The Jackson Laboratory ...
Microsoft Translator or Bing Translator is a multilingual machine translation cloud service provided by Microsoft.Microsoft Translator is a part of Microsoft Cognitive Services [1] and integrated across multiple consumer, developer, and enterprise products, including Bing, Microsoft Office, SharePoint, Microsoft Edge, Microsoft Lync, Yammer, Skype Translator, Visual Studio, and Microsoft ...
It is important to note that the use of SCID mice has been questioned as a model for studying the human immune system. Some studies have suggested that after a period of time, human T cells in the immunocompromised mice become anergic, meaning that they no longer respond to stimuli. Thus, these mice may be able to host a human immune system ...
The word "syngenic" or "syngeneic" (from the Greek word for a relative) means genetically identical, or sufficiently identical and immunologically compatible as to allow for transplantation. For example, it may be used for something transplanted from an identical twin .
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Patient derived xenografts (PDX) are models of cancer where the tissue or cells from a patient's tumor are implanted into an immunodeficient or humanized mouse. [1] It is a form of xenotransplantation. PDX models are used to create an environment that allows for the continued growth of cancer after its removal from a patient.
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