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DNA nanotechnology, specifically, is an example of bottom-up molecular self-assembly, in which molecular components spontaneously organize into stable structures; the particular form of these structures is induced by the physical and chemical properties of the components selected by the designers. [19]
Nucleic acid design is used in DNA nanotechnology to design strands which will self-assemble into a desired target structure. These include examples such as DNA machines, periodic two- and three-dimensional lattices, polyhedra, and DNA origami. [2]
Download as PDF; Printable version; In other projects Wikimedia Commons; ... This is the category for articles related to DNA nanotechnology as well as DNA computing
DNA origami structures can be designed with specific attachment sites for other nanoscale components, such as nanoparticles, fluorophores, or proteins. By measuring the distances between these components on the origami structures, researchers can perform precise distance measurements at the nanoscale through atomic force microscopy (AFM) and ...
Single-stranded and double-stranded versions of these materials have been created using, for example, DNA, LNA, and RNA. One- and two-dimensional forms of nucleic acids (e.g., single strands, linear duplexes, and plasmids ) (Fig. 1) are important biological machinery for the storage and transmission of genetic information .
Molecular models are useful in the design of structures for DNA nanotechnology. Here, individual DNA tiles (model at left) self-assemble into a highly ordered DNA 2D-nanogrid (AFM image at right). There are various uses of DNA molecular modeling in Genomics and Biotechnology research applications, from DNA repair to PCR and DNA nanostructures.
For example, they could be used to identify and destroy cancer cells. [ 83 ] [ 84 ] Molecular nanotechnology is a speculative subfield of nanotechnology regarding the possibility of engineering molecular assemblers , biological machines which could re-order matter at a molecular or atomic scale.
Molecular self-assembly is a key concept in supramolecular chemistry. [6] [7] [8] This is because assembly of molecules in such systems is directed through non-covalent interactions (e.g., hydrogen bonding, metal coordination, hydrophobic forces, van der Waals forces, pi-stacking interactions, and/or electrostatic) as well as electromagnetic interactions.