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Linezolid binds to the 23S portion of the 50S subunit (the center of peptidyl transferase activity), [9] [101] close to the binding sites of chloramphenicol, lincomycin, and other antibiotics. Due to this unique mechanism of action, cross-resistance between linezolid and other protein synthesis inhibitors is highly infrequent or nonexistent ...
Mechanism of action: Enzyme inhibitor: Biological target: Monoamine oxidase enzymes: ... Linezolid is an antibiotic drug with weak, reversible MAO-inhibiting activity.
Same mode of action as other beta-lactam antibiotics: disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. Nitrofurans; Furazolidone: Furoxone: Bacterial or protozoal diarrhea or enteritis: Nitrofurantoin(Bs) Macrodantin, Macrobid: Urinary tract infections: Oxazolidinones(Bs) Linezolid: Zyvox: VRSA: Thrombocytopenia ...
Following a 40-year break in discovering classes of antibacterial compounds, four new classes of antibiotics were introduced to clinical use in the late 2000s and early 2010s: cyclic lipopeptides (such as daptomycin), glycylcyclines (such as tigecycline), oxazolidinones (such as linezolid), and lipiarmycins (such as fidaxomicin).
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Mechanism of action. Quinupristin and dalfopristin are protein synthesis inhibitors in a synergistic manner. While each of the two is only a bacteriostatic agent, ...
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Rivaroxaban bears a striking structural similarity to the antibiotic linezolid: both drugs share the same oxazolidinone-derived core structure. [39] Accordingly, rivaroxaban was studied for any possible antimicrobial effects and for the possibility of mitochondrial toxicity , which is a known complication of long-term linezolid use. [ 40 ]
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