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  2. Amide reduction - Wikipedia

    en.wikipedia.org/wiki/Amide_reduction

    Some amides can be reduced to aldehydes in the Sonn-Müller method, but most routes to aldehydes involve a well-chosen organometallic reductant. Lithium aluminum hydride reduces an excess of N,N-disubstituted amides to an aldehyde: [citation needed] R(CO)NRR' + LiAlH 4 → RCHO + HNRR' With further reduction the alcohol is obtained.

  3. Weinreb ketone synthesis - Wikipedia

    en.wikipedia.org/wiki/Weinreb_ketone_synthesis

    Nahm and Weinreb also reported the synthesis of aldehydes by reduction of the amide with an excess of lithium aluminum hydride (see amide reduction). The Weinreb–Nahm ketone synthesis. The major advantage of this method over addition of organometallic reagents to more typical acyl compounds is that it avoids the common problem of over-addition.

  4. Schmidt reaction - Wikipedia

    en.wikipedia.org/wiki/Schmidt_reaction

    In organic chemistry, the Schmidt reaction is an organic reaction in which an azide reacts with a carbonyl derivative, usually an aldehyde, ketone, or carboxylic acid, under acidic conditions to give an amine or amide, with expulsion of nitrogen.

  5. Schwartz's reagent - Wikipedia

    en.wikipedia.org/wiki/Schwartz's_reagent

    Schwartz's reagent reduces amides to aldehydes. [11] Vinylation of ketones in high yields is a possible use of Schwartz's reagent. [12] Schwartz's reagent has been used in the synthesis of some macrolide antibiotics, [13] [14] (−)-motuporin, [15] and antitumor agents. [16]

  6. Vilsmeier–Haack reaction - Wikipedia

    en.wikipedia.org/wiki/Vilsmeier–Haack_reaction

    The reaction of a substituted amide with phosphorus oxychloride gives a substituted chloroiminium ion (2), also called the Vilsmeier reagent. The initial product is an iminium ion (4b), which is hydrolyzed to the corresponding ketone or aldehyde during workup. [7] The Vilsmeier–Haack reaction

  7. Weerman degradation - Wikipedia

    en.wikipedia.org/wiki/Weerman_degradation

    Weerman degradation, also named Weerman reaction, is a name reaction in organic chemistry.It is named after Rudolf Adrian Weerman, who discovered it in 1910. [1] In general, it is an organic reaction in carbohydrate chemistry in which amides are degraded by sodium hypochlorite, forming an aldehyde with one less carbon. [2]

  8. Hofmann rearrangement - Wikipedia

    en.wikipedia.org/wiki/Hofmann_rearrangement

    The Hofmann rearrangement (Hofmann degradation) is the organic reaction of a primary amide to a primary amine with one less carbon atom. [1] [2] [3] The reaction involves oxidation of the nitrogen followed by rearrangement of the carbonyl and nitrogen to give an isocyanate intermediate.

  9. Amide - Wikipedia

    en.wikipedia.org/wiki/Amide

    The core −C(=O)−(N) of amides is called the amide group (specifically, carboxamide group). In the usual nomenclature, one adds the term "amide" to the stem of the parent acid's name. For instance, the amide derived from acetic acid is named acetamide (CH 3 CONH 2). IUPAC recommends ethanamide, but this and related formal names are rarely ...