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Monocyte distribution width (MDW) is a cytometry-based parameter that measures the range of variation of monocytes. If the parameter is available, it is reported as part of the standard complete blood count (CBC) with differential. [1] The parameter was FDA cleared as an early sepsis indicator for ER patients in 2019 for Beckman Coulter. [2] [3]
RDW-CV "width" refers to the width of the volume curve (distribution width), not the width of the cells. [5] [6] RDW-SD is calculated as the width (in fL) of the RBC size distribution histogram at the 20% height level. This parameter is, therefore, not influenced by the average RBC size (mean corpuscular volume, MCV). [7]
Monocytes are a type of leukocyte or white blood cell. They are the largest type of leukocyte in blood and can differentiate into macrophages and monocyte-derived ...
A white blood cell differential is a medical laboratory test that provides information about the types and amounts of white blood cells in a person's blood. The test, which is usually ordered as part of a complete blood count (CBC), measures the amounts of the five normal white blood cell types – neutrophils, lymphocytes, monocytes, eosinophils and basophils – as well as abnormal cell ...
Red blood cell distribution width (RDW or RDW-CV or RCDW and RDW-SD) is a measure of the range of variation of red blood cell (RBC) volume, yielding clues about morphology. [ citation needed ] Erythropoietic precursor indices
For further specification, it can be used to calculate red blood cell distribution width (RDW). The RDW is a statistical calculation made by automated analyzers that reflects the variability in size and shape of the RBCs.
Monocytes, the largest type of white blood cell, share the "vacuum cleaner" (phagocytosis) function of neutrophils, but are much longer lived as they have an extra role: they present pieces of pathogens to T cells so that the pathogens may be recognized again and killed. This causes an antibody response to be mounted.
Anisocytosis is a medical term meaning that a patient's red blood cells are of unequal size. This is commonly found in anemia and other blood conditions. False diagnostic flagging may be triggered on a complete blood count by an elevated WBC count, agglutinated RBCs, RBC fragments, giant platelets or platelet clumps due to anisocytosis.